Journal Article

PUBDB-2024-05770

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png CXCR5$^+$PD-1$^{++}$ CD4$^+$ T cells colonize infant intestines early in life and promote B cell maturation

Jordan-Paiz, A. ; Martrus, G. ; Steinert, F. L. ; Kaufmann, M. ; Sagebiel, A. F. ; Schreurs, R. R. C. E. ; Rechtien, A. ; Baumdick, M. E. ; Jung, J. M. ; Möller, K. J. ; Wegner, L. ; Grüttner, C. ; Richert, L. ; Thünauer, R.Extern*CSSB* ; Schroeder-Schwarz, J. ; van Goudoever, J. B. ; Geijtenbeek, T. B. H. ; Altfeld, M. ; Pals, S. T. ; Perez, D. ; Klarenbeek, P. L. ; Tomuschat, C. ; Sauter, G. ; Königs, I. ; Schumacher, U. ; Friese, M. A. ; Melling, N. ; Reinshagen, K. ; Bunders, M. J. (Corresponding author)

2023
Nature Publ. Group London [u.a.]

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Please use a persistent id in citations: doi:10.1038/s41423-022-00944-4

Abstract: Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++ CD4+ T cells (TFH cells). We investigated the ontogeny of CXCR5+PD-1++ CD4+ T cells in human intestines. While CXCR5+PD-1++ CD4+ T cells were absent in fetal intestines, CXCR5+PD-1++ CD4+ T cells increased after birth and were abundant in infant intestines, resulting in significant higher numbers compared to adults. These findings were supported by scRNAseq analyses, showing increased frequencies of CD4+ T cells with a TFH gene signature in infant intestines compared to blood. Co-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+ T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B cells. Taken together, we demonstrate that functional TFH cells are numerous in infant intestines, making them a promising target for oral pediatric vaccine strategies.

Note: MK is supported by a Walter Benjamin Fellowship of the Deutsche Forschungsgemeinschaft (KA5554/1-1, KA5554/1-2).

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Contributing Institute(s):

1. CSSB-CF-ALFM (CSSB-CF-ALFM)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Experiment(s):

1. No specific instrument

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Essential Science Indicators ; IF >= 20 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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