TY  - JOUR
AU  - Jordan-Paiz, Ana
AU  - Martrus, Glòria
AU  - Steinert, Fenja L.
AU  - Kaufmann, Max
AU  - Sagebiel, Adrian F.
AU  - Schreurs, Renée R. C. E.
AU  - Rechtien, Anne
AU  - Baumdick, Martin E.
AU  - Jung, Johannes M.
AU  - Möller, Kimberly J.
AU  - Wegner, Lucy
AU  - Grüttner, Cordula
AU  - Richert, Laura
AU  - Thünauer, Roland
AU  - Schroeder-Schwarz, Jennifer
AU  - van Goudoever, Johannes B.
AU  - Geijtenbeek, Teunis B. H.
AU  - Altfeld, Marcus
AU  - Pals, Steven T.
AU  - Perez, Daniel
AU  - Klarenbeek, Paul L.
AU  - Tomuschat, Christian
AU  - Sauter, Guido
AU  - Königs, Ingo
AU  - Schumacher, Udo
AU  - Friese, Manuel A.
AU  - Melling, Nathaniel
AU  - Reinshagen, Konrad
AU  - Bunders, Madeleine J.
TI  - CXCR5<sup>+</sup>PD-1<sup>++</sup> CD4<sup>+</sup> T cells colonize infant intestines early in life and promote B cell maturation 
JO  - Cellular & molecular immunology
VL  - 20
IS  - 2
SN  - 1672-7681
CY  - London [u.a.]
PB  - Nature Publ. Group
M1  - PUBDB-2024-05770
SP  - 201 - 213
PY  - 2023
N1  - MK is supported by a Walter Benjamin Fellowship of the Deutsche Forschungsgemeinschaft (KA5554/1-1, KA5554/1-2). 
AB  - Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++ CD4+ T cells (TFH cells). We investigated the ontogeny of CXCR5+PD-1++ CD4+ T cells in human intestines. While CXCR5+PD-1++ CD4+ T cells were absent in fetal intestines, CXCR5+PD-1++ CD4+ T cells increased after birth and were abundant in infant intestines, resulting in significant higher numbers compared to adults. These findings were supported by scRNAseq analyses, showing increased frequencies of CD4+ T cells with a TFH gene signature in infant intestines compared to blood. Co-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+ T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B cells. Taken together, we demonstrate that functional TFH cells are numerous in infant intestines, making them a promising target for oral pediatric vaccine strategies. 
LB  - PUB:(DE-HGF)16
C6  - pmid:36600048
UR  - <Go to ISI:>//WOS:000907946300001
DO  - DOI:10.1038/s41423-022-00944-4
UR  - https://bib-pubdb1.desy.de/record/614230
ER  -