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2025-07-09
18:00
OpenAccess [PUBDB-2025-02293] Journal Article
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Myricetin-bound crystal structure of the SARS-CoV-2 helicase NSP13 facilitates the discovery of novel natural inhibitors
The SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target for antiviral drug development. Here, we present the 2 Å resolution crystal structure of NSP13 bound to the natural flavonoid myricetin, revealing a conserved allosteric binding site. [...]
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2025-07-09
16:45
OpenAccess [PUBDB-2025-02292] Journal Article
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Novel Derivatives of 3-Amino-4-hydroxy-benzenesulfonamide: Synthesis, Binding to Carbonic Anhydrases, and Activity in Cancer Cell 2D and 3D Cultures
first_pagesettingsOrder Article ReprintsOpen AccessArticleNovel Derivatives of 3-Amino-4-hydroxy-benzenesulfonamide: Synthesis, Binding to Carbonic Anhydrases, and Activity in Cancer Cell 2D and 3D Culturesby Valdas Vainauskas1, Rugilė Norvaišaitė2, Birutė Grybaitė1 [ORCID] , Rita Vaickelionienė1, Alexey Smirnov2, Tautvydas Kojis2 [ORCID] , Lina Baranauskiene2 [ORCID] , Elena Manakova3 [ORCID] , Saulius Gražulis4, Asta Zubrienė2 [ORCID] , Daumantas Matulis2 [ORCID] , Vytautas Mickevičius1,* [ORCID] and Vilma Petrikaitė5,6,*1Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania2Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania3Department of Protein–DNA Interactions, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio al. [...]
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2025-07-09
16:36
[PUBDB-2025-02291] Journal Article
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TIR domains produce histidine-ADPR as an immune signal in bacteria
Nature 642(8067), 467 - 473 () [10.1038/s41586-025-08930-2]  GO
Toll/interleukin-1 receptor (TIR) domains are central components of pattern recognition immune proteins across all domains of life1,2. In bacteria and plants, TIR-domain proteins recognize pathogen invasion and then produce immune signalling molecules exclusively comprising nucleotide moieties2,3,4,5. [...]
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2025-07-09
16:21
OpenAccess [PUBDB-2025-02290] Journal Article
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Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV
Biomolecules 15(7), 944 - () [10.3390/biom15070944]  GO
The ReAV enzyme from Rhizobium etli, a representative of Class 3 L-asparaginases, is sequentially and structurally different from other known L-asparaginases. This distinctiveness makes ReAV a candidate for novel antileukemic therapies. [...]
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2025-07-09
16:08
OpenAccess [PUBDB-2025-02288] Journal Article
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Unveiling the structure, function and dynamics of StmPr1 in Stenotrophomonas maltophilia virulence
The increase in infections caused by multi-resistant Gram-negative bacteria, like Stenotrophomonas maltophilia, has become a growing health crisis worldwide. S. [...]
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2025-07-09
11:26
OpenAccess [PUBDB-2025-02278] Preprint
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Observation of $t\bar{t}\gamma\gamma$ production at $\sqrt{s}=$13 TeV with the ATLAS detector
[CERN-EP-2025-125; arXiv:2506.05018]
This paper presents the first observation of top-quark pair production in association with two photons ($t\bar{t}\gamma\gamma$). The measurement is performed in the single-lepton decay channel using proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider. [...]
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2025-07-09
11:20
[PUBDB-2025-02276] Contribution to a book
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The Structure of the Type III Secretion System Needle Complex
[Ebook] Bacterial Type III Protein Secretion Systems / Wagner, Samuel ; Galán, Jorge E. , Cham : Springer International Publishing, 2020, Cham : Springer, Current Topics in Microbiology and Immunology 427, 67 – 90 () [https://doi.org/10.1007/82_2019_178]  GO
Introduction -- Evolution of type III secretion systems -- Transcriptional and post-transcriptional regulatory mechanisms controlling type III secretion -- Assembly of type III secretion machines -- Structure of the type III secretion needle complex -- Structure and assembly of filamentous structures associated with type III secretion machines -- Structure and function of the type III secretion-associated sorting platform -- Molecular organization and assembly of the protein export apparatus -- Export mechanisms and energy transduction in type III secretion machines -- Needle length control and substrate switching in type III secretion machines -- The tip complex: sensing the host cell -- Chaperones and targeting mechanisms

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2025-07-09
11:17
OpenAccess [PUBDB-2025-02275] Preprint
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Search for single production of vector-like quarks decaying into $W(\ell ν)b$ in $pp$ collisions at $\sqrt{s} = 13$ TeV with the ATLAS detector
[CERN-EP-2025-098; arXiv:2506.15515]
A search for single production of a vector-like quark $Q$, which could be either a singlet $T$, with charge $\tfrac23$, or a $Y$ from a $(T,B,Y)$ triplet, with charge $-\tfrac43$, is performed using data from proton-proton collisions at a centre-of-mass energy of 13 TeV. The data correspond to the full integrated luminosity of 140 fb$^{-1}$ recorded with the ATLAS detector during Run 2 of the Large Hadron Collider. [...]
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2025-07-09
11:13
OpenAccess [PUBDB-2025-02274] Preprint

Search for squarks and gluinos in $pp$ collisions at $\sqrt{s} = 13$ TeV and $13.6$ TeV in events with $τ$-leptons, jets and missing transverse momentum using the ATLAS detector
[CERN-EP-2025-132; arXiv:2507.00296]
A search for R-parity-conserving supersymmetry in events with large missing transverse momentum, jets and at least one hadronically decaying $τ$-lepton is presented. Both gluino and squark pair production are considered, with the cascade decay of each gluino or squark producing either a $τ$-slepton or a $τ$-sneutrino. [...]
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2025-07-09
11:10
OpenAccess [PUBDB-2025-02273] Preprint
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Search for decays of the Higgs boson into scalar particles decaying into four or six $b$-quarks using $pp$ collisions at $\sqrt{s}= 13\,\mathrm{TeV}$ with the ATLAS detector
[CERN-EP-2025-121; arXiv:2507.01165]
A search for exotic decays of the Higgs boson $H$ into new scalar or pseudoscalar particles that subsequently decay into $b$-quarks is presented. The search considers $ZH$ production with several decay scenarios for the Higgs boson: first to a pair of identical scalars, $H\rightarrow 2a \rightarrow 4b$, second to a pair of scalars with different masses ($m_{a1}<m_{a2}$), either directly, $H\rightarrow a_1a_2 \rightarrow 4b$, or via a longer decay chain, $H \rightarrow a_1a_2 \rightarrow 3a_1 \rightarrow 6b$. [...]
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