Publications database

The SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target for antiviral drug development. Here, we present the 2 Å resolution crystal structure of NSP13 bound to the natural flavonoid myricetin, revealing a conserved allosteric binding site. [...]

first_pagesettingsOrder Article ReprintsOpen AccessArticleNovel Derivatives of 3-Amino-4-hydroxy-benzenesulfonamide: Synthesis, Binding to Carbonic Anhydrases, and Activity in Cancer Cell 2D and 3D Culturesby Valdas Vainauskas1, Rugilė Norvaišaitė2, Birutė Grybaitė1 [ORCID] , Rita Vaickelionienė1, Alexey Smirnov2, Tautvydas Kojis2 [ORCID] , Lina Baranauskiene2 [ORCID] , Elena Manakova3 [ORCID] , Saulius Gražulis4, Asta Zubrienė2 [ORCID] , Daumantas Matulis2 [ORCID] , Vytautas Mickevičius1,* [ORCID] and Vilma Petrikaitė5,6,*1Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania2Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania3Department of Protein–DNA Interactions, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio al. [...]

Toll/interleukin-1 receptor (TIR) domains are central components of pattern recognition immune proteins across all domains of life1,2. In bacteria and plants, TIR-domain proteins recognize pathogen invasion and then produce immune signalling molecules exclusively comprising nucleotide moieties2,3,4,5. [...]

The ReAV enzyme from Rhizobium etli, a representative of Class 3 L-asparaginases, is sequentially and structurally different from other known L-asparaginases. This distinctiveness makes ReAV a candidate for novel antileukemic therapies. [...]

The increase in infections caused by multi-resistant Gram-negative bacteria, like Stenotrophomonas maltophilia, has become a growing health crisis worldwide. S. [...]

This paper presents the first observation of top-quark pair production in association with two photons ($t\bar{t}\gamma\gamma$). The measurement is performed in the single-lepton decay channel using proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider. [...]

Introduction -- Evolution of type III secretion systems -- Transcriptional and post-transcriptional regulatory mechanisms controlling type III secretion -- Assembly of type III secretion machines -- Structure of the type III secretion needle complex -- Structure and assembly of filamentous structures associated with type III secretion machines -- Structure and function of the type III secretion-associated sorting platform -- Molecular organization and assembly of the protein export apparatus -- Export mechanisms and energy transduction in type III secretion machines -- Needle length control and substrate switching in type III secretion machines -- The tip complex: sensing the host cell -- Chaperones and targeting mechanisms

A search for single production of a vector-like quark $Q$, which could be either a singlet $T$, with charge $\tfrac23$, or a $Y$ from a $(T,B,Y)$ triplet, with charge $-\tfrac43$, is performed using data from proton-proton collisions at a centre-of-mass energy of 13 TeV. The data correspond to the full integrated luminosity of 140 fb$^{-1}$ recorded with the ATLAS detector during Run 2 of the Large Hadron Collider. [...]

A search for R-parity-conserving supersymmetry in events with large missing transverse momentum, jets and at least one hadronically decaying $τ$-lepton is presented. Both gluino and squark pair production are considered, with the cascade decay of each gluino or squark producing either a $τ$-slepton or a $τ$-sneutrino. [...]

A search for exotic decays of the Higgs boson $H$ into new scalar or pseudoscalar particles that subsequently decay into $b$-quarks is presented. The search considers $ZH$ production with several decay scenarios for the Higgs boson: first to a pair of identical scalars, $H\rightarrow 2a \rightarrow 4b$, second to a pair of scalars with different masses ($m_{a1}<m_{a2}$), either directly, $H\rightarrow a_1a_2 \rightarrow 4b$, or via a longer decay chain, $H \rightarrow a_1a_2 \rightarrow 3a_1 \rightarrow 6b$. [...]