Journal Article

Plasmodium species are protozoan parasites causing the deadly malaria disease. They have developed effective resistance mechanisms against most antimalarial medication, causing an urgent need to identify new antimalarial drug targets [...]

Multiwavelength observation of the gamma-ray burst, GRB 190114C, opens a new window for studying the emission mechanism of GRB afterglows. Its very high energy (VHE; ≳ 100 GeV) detection has motivated an inverse Compton interpretation for the emission, but this has not been tested. [...]

Fifty thousand hybrid circuits of five different types will be manufactured for the Phase-2 Upgrade of the CMS Outer Tracker. These circuits must undergo a strict quality control process, composed of functional testing and visual inspection, before they can be assembled into modules. [...]

The energy-resolving performance of a synchrotron radiation monochromator can be characterised by measuring the fluorescence response of a gas in scans across characteristic absorption lines. Here, we describe a method using exceptionally narrow absorption features in the soft x-ray range [...]

The ‘660’ discontinuity is often associated with a phase transitions in pyrolite at about 24 GPa. There are ubiquitous reports of seismic anisotropy below the ‘660’ which are difficult to explain from a mineralogical point of view. [...]

Drug and fragment screening at X-ray crystallography beamlines has been a huge success. However, it is inevitable that more high-profile biological drug targets will be identified for which high-quality, highly homogenous crystal systems cannot be found. [...]

In this report, we describe a truncated Deinococcus radiodurans 1-deoxy-D-xylulose-5-phosphate synthase (DXS) protein that retains enzymatic activity, while slowing protein degradation and showing improved crystallization properties. With modern drug-design approaches relying heavily on the elucidation of atomic interactions of potential new drugs with their targets, the need for co-crystal structures with the compounds of interest is high [...]

Third-generation synchrotron radiation sources with improving new techniques provide opportunities to perform many promising experiments. X-ray Raman scattering (XRS) is one of the synchrotron radiation based techniques for the investigation of soft X-ray absorption edges (∼50-1000 eV) using hard X-rays (∼10 keV). [...]

Amorphous Ti$_x$O$_y$ with high surface area has attracted significant interest as photocatalyst with higher activity in ultraviolet (UV) light-induced water splitting applications compared to commercial nanocrystalline TiO$_2$. Under photocatalytic operation conditions, the structure of the molecular titanium alkoxide precursor rearranges upon hydrolysis and leads to higher connectivity of the structure-building units [...]

In this work, we optimize the setups and experimental parameters of X-ray phase-contrast computed-tomography for the three-dimensional imaging of the cyto- and myeloarchitecture of cerebral cortex, including both human and murine tissue. We present examples for different optical configurations using state-of-the art synchrotron instruments for holographic tomography, as well as compact laboratory setups for phase-contrast tomography in the direct contrast (edge-enhancement) regime [...]