Journal Article

Genetically encoded biosensors enable the monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational biosensor design approach using Constraint Network Analysis to identify optimal insertion sites for reporter modules in molecular recognition elements (MREs). [...]

A water-soluble hydroxypropyl cellulose (HPC) polymer matrix has been filled with different weight percentages (wt.%) of multiwalled carbon nanotubes (MWCNTs), fullerenes C60, fullerenols C60(OH)24, and their combinations. We study the potential of the 0D nanoparticles for improving electrical properties of the conductive MWCNT network in a biocompatible matrix. [...]

Spermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegeneration, and other diseases. Despite its significance, the mechanistic details of spermine remain incompletely understood. [...]

RNA aptamers obtained from in vitro selection experiments provide unique insights into the structural properties and ligand recognition capabilities of RNA in general. In order to investigate the relationships between RNA sequence information content and structural complexity with ligand affinity and specificity, the Szostak group previously identified eleven different families of GTP-binding aptamers varying widely in their sequence conservation patterns as well as in their secondary structure complexity and topology. [...]

Tau is a microtubule-associated protein that plays a critical role in regulating the organization and stability of microtubules (MTs) in neurons. Although the association of tau with MTs is well recognized, the structural consequences of its binding at steady state have remained poorly understood. [...]

Synthetic glycolipids and similar amphiphils with peptide and other head groups have been designed for labeling/modification of living cells under mild physiological conditions. Under-standing the mechanism of their penetration through the cellular glycocalyx and subsequent insertion into the plasma membrane opens up the prospect of improving the recently found anti-tumor properties of such constructs. [...]

Once a year, the International Committee for Future Accelerators (ICFA) assembles for an in-person meeting, typically attached to a major summer conference. The 99th edition took place on 24 August at the Wisconsin IceCube Particle Astrophysics Center in downtown Madison, one day before Lepton–Photon 2025. [...]

In response to increasing data challenges, CMS has adopted the use of GPU offloading at the High-Level Trigger (HLT). However, GPU code is often hardware specific, and increases the maintenance burden on software development. [...]

We introduce the new idea of a nonlinear active plasma lens, as part of a larger transport lattice for achromatic electron beam transport. The proposed implementation uses an external dipole magnet acting on a plasma and is motivated by 1D-hydrodynamic simulations. [...]

The aim of this study is to explore the internal damage mechanisms of AlSi12 metal matrix syntactic foam (MMSF) with embedded ceramic hollow spheres (CHSs) to understand the damage behavior during compressive loading. To achieve this goal, in situ synchrotron X-ray tomography is used. [...]