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000614230 1001_ $$00000-0002-3495-7201$$aJordan-Paiz, Ana$$b0
000614230 245__ $$aCXCR5$^+$PD-1$^{++}$ CD4$^+$ T cells colonize infant intestines early in life and promote B cell maturation 
000614230 260__ $$aLondon [u.a.]$$bNature Publ. Group$$c2023
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000614230 500__ $$aMK is supported by a Walter Benjamin Fellowship of the Deutsche Forschungsgemeinschaft (KA5554/1-1, KA5554/1-2). 
000614230 520__ $$aGastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++ CD4+ T cells (TFH cells). We investigated the ontogeny of CXCR5+PD-1++ CD4+ T cells in human intestines. While CXCR5+PD-1++ CD4+ T cells were absent in fetal intestines, CXCR5+PD-1++ CD4+ T cells increased after birth and were abundant in infant intestines, resulting in significant higher numbers compared to adults. These findings were supported by scRNAseq analyses, showing increased frequencies of CD4+ T cells with a TFH gene signature in infant intestines compared to blood. Co-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+ T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B cells. Taken together, we demonstrate that functional TFH cells are numerous in infant intestines, making them a promising target for oral pediatric vaccine strategies. 
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000614230 7001_ $$aMartrus, Glòria$$b1
000614230 7001_ $$aSteinert, Fenja L.$$b2
000614230 7001_ $$aKaufmann, Max$$b3
000614230 7001_ $$aSagebiel, Adrian F.$$b4
000614230 7001_ $$aSchreurs, Renée R. C. E.$$b5
000614230 7001_ $$aRechtien, Anne$$b6
000614230 7001_ $$00000-0001-5948-8109$$aBaumdick, Martin E.$$b7
000614230 7001_ $$aJung, Johannes M.$$b8
000614230 7001_ $$00000-0003-2254-3025$$aMöller, Kimberly J.$$b9
000614230 7001_ $$aWegner, Lucy$$b10
000614230 7001_ $$aGrüttner, Cordula$$b11
000614230 7001_ $$aRichert, Laura$$b12
000614230 7001_ $$0P:(DE-H253)PIP1087856$$aThünauer, Roland$$b13
000614230 7001_ $$aSchroeder-Schwarz, Jennifer$$b14
000614230 7001_ $$avan Goudoever, Johannes B.$$b15
000614230 7001_ $$aGeijtenbeek, Teunis B. H.$$b16
000614230 7001_ $$aAltfeld, Marcus$$b17
000614230 7001_ $$aPals, Steven T.$$b18
000614230 7001_ $$aPerez, Daniel$$b19
000614230 7001_ $$aKlarenbeek, Paul L.$$b20
000614230 7001_ $$aTomuschat, Christian$$b21
000614230 7001_ $$aSauter, Guido$$b22
000614230 7001_ $$aKönigs, Ingo$$b23
000614230 7001_ $$aSchumacher, Udo$$b24
000614230 7001_ $$aFriese, Manuel A.$$b25
000614230 7001_ $$aMelling, Nathaniel$$b26
000614230 7001_ $$aReinshagen, Konrad$$b27
000614230 7001_ $$0P:(DE-HGF)0$$aBunders, Madeleine J.$$b28$$eCorresponding author
000614230 773__ $$0PERI:(DE-600)2219471-X$$a10.1038/s41423-022-00944-4$$gVol. 20, no. 2, p. 201 - 213$$n2$$p201 - 213$$tCellular & molecular immunology$$v20$$x1672-7681$$y2023
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