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@ARTICLE{JordanPaiz:614230,
      author       = {Jordan-Paiz, Ana and Martrus, Glòria and Steinert, Fenja
                      L. and Kaufmann, Max and Sagebiel, Adrian F. and Schreurs,
                      Renée R. C. E. and Rechtien, Anne and Baumdick, Martin E.
                      and Jung, Johannes M. and Möller, Kimberly J. and Wegner,
                      Lucy and Grüttner, Cordula and Richert, Laura and
                      Thünauer, Roland and Schroeder-Schwarz, Jennifer and van
                      Goudoever, Johannes B. and Geijtenbeek, Teunis B. H. and
                      Altfeld, Marcus and Pals, Steven T. and Perez, Daniel and
                      Klarenbeek, Paul L. and Tomuschat, Christian and Sauter,
                      Guido and Königs, Ingo and Schumacher, Udo and Friese,
                      Manuel A. and Melling, Nathaniel and Reinshagen, Konrad and
                      Bunders, Madeleine J.},
      title        = {{CXCR}5$^+${PD}-1$^{++}$ {CD}4$^+$ {T} cells colonize
                      infant intestines early in life and promote {B} cell
                      maturation},
      journal      = {Cellular $\&$ molecular immunology},
      volume       = {20},
      number       = {2},
      issn         = {1672-7681},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {PUBDB-2024-05770},
      pages        = {201 - 213},
      year         = {2023},
      note         = {MK is supported by a Walter Benjamin Fellowship of the
                      Deutsche Forschungsgemeinschaft (KA5554/1-1, KA5554/1-2).},
      abstract     = {Gastrointestinal infections are a major cause for serious
                      clinical complications in infants. The induction of antibody
                      responses by B cells is critical for protective immunity
                      against infections and requires CXCR5+PD-1++ CD4+ T cells
                      (TFH cells). We investigated the ontogeny of CXCR5+PD-1++
                      CD4+ T cells in human intestines. While CXCR5+PD-1++ CD4+ T
                      cells were absent in fetal intestines, CXCR5+PD-1++ CD4+ T
                      cells increased after birth and were abundant in infant
                      intestines, resulting in significant higher numbers compared
                      to adults. These findings were supported by scRNAseq
                      analyses, showing increased frequencies of CD4+ T cells with
                      a TFH gene signature in infant intestines compared to blood.
                      Co-cultures of autologous infant intestinal
                      CXCR5+PD-1+/−CD4+ T cells with B cells further
                      demonstrated that infant intestinal TFH cells were able to
                      effectively promote class switching and antibody production
                      by B cells. Taken together, we demonstrate that functional
                      TFH cells are numerous in infant intestines, making them a
                      promising target for oral pediatric vaccine strategies.},
      cin          = {CSSB-CF-ALFM},
      ddc          = {610},
      cid          = {I:(DE-H253)CSSB-CF-ALFM-20210629},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36600048},
      UT           = {WOS:000907946300001},
      doi          = {10.1038/s41423-022-00944-4},
      url          = {https://bib-pubdb1.desy.de/record/614230},
}