%0 Journal Article
%A Jordan-Paiz, Ana
%A Martrus, Glòria
%A Steinert, Fenja L.
%A Kaufmann, Max
%A Sagebiel, Adrian F.
%A Schreurs, Renée R. C. E.
%A Rechtien, Anne
%A Baumdick, Martin E.
%A Jung, Johannes M.
%A Möller, Kimberly J.
%A Wegner, Lucy
%A Grüttner, Cordula
%A Richert, Laura
%A Thünauer, Roland
%A Schroeder-Schwarz, Jennifer
%A van Goudoever, Johannes B.
%A Geijtenbeek, Teunis B. H.
%A Altfeld, Marcus
%A Pals, Steven T.
%A Perez, Daniel
%A Klarenbeek, Paul L.
%A Tomuschat, Christian
%A Sauter, Guido
%A Königs, Ingo
%A Schumacher, Udo
%A Friese, Manuel A.
%A Melling, Nathaniel
%A Reinshagen, Konrad
%A Bunders, Madeleine J.
%T CXCR5<sup>+</sup>PD-1<sup>++</sup> CD4<sup>+</sup> T cells colonize infant intestines early in life and promote B cell maturation 
%J Cellular & molecular immunology
%V 20
%N 2
%@ 1672-7681
%C London [u.a.]
%I Nature Publ. Group
%M PUBDB-2024-05770
%P 201 - 213
%D 2023
%Z MK is supported by a Walter Benjamin Fellowship of the Deutsche Forschungsgemeinschaft (KA5554/1-1, KA5554/1-2). 
%X Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++ CD4+ T cells (TFH cells). We investigated the ontogeny of CXCR5+PD-1++ CD4+ T cells in human intestines. While CXCR5+PD-1++ CD4+ T cells were absent in fetal intestines, CXCR5+PD-1++ CD4+ T cells increased after birth and were abundant in infant intestines, resulting in significant higher numbers compared to adults. These findings were supported by scRNAseq analyses, showing increased frequencies of CD4+ T cells with a TFH gene signature in infant intestines compared to blood. Co-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+ T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B cells. Taken together, we demonstrate that functional TFH cells are numerous in infant intestines, making them a promising target for oral pediatric vaccine strategies. 
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36600048
%U <Go to ISI:>//WOS:000907946300001
%R 10.1038/s41423-022-00944-4
%U https://bib-pubdb1.desy.de/record/614230