Home > Publications database > CXCR5$^+$PD-1$^{++}$ CD4$^+$ T cells colonize infant intestines early in life and promote B cell maturation > print

001     614230
005     20250929153730.0
024 7 _ |a 10.1038/s41423-022-00944-4
|2 doi
024 7 _ |a 1672-7681
|2 ISSN
024 7 _ |a 2042-0226
|2 ISSN
024 7 _ |a altmetric:141026744
|2 altmetric
024 7 _ |a pmid:36600048
|2 pmid
024 7 _ |a WOS:000907946300001
|2 WOS
024 7 _ |a openalex:W4313545802
|2 openalex
037 _ _ |a PUBDB-2024-05770
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Jordan-Paiz, Ana
|0 0000-0002-3495-7201
|b 0
245 _ _ |a CXCR5$^+$PD-1$^{++}$ CD4$^+$ T cells colonize infant intestines early in life and promote B cell maturation
260 _ _ |a London [u.a.]
|c 2023
|b Nature Publ. Group
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1728994593_1762817
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a MK is supported by a Walter Benjamin Fellowship of the Deutsche Forschungsgemeinschaft (KA5554/1-1, KA5554/1-2).
520 _ _ |a Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++ CD4+ T cells (TFH cells). We investigated the ontogeny of CXCR5+PD-1++ CD4+ T cells in human intestines. While CXCR5+PD-1++ CD4+ T cells were absent in fetal intestines, CXCR5+PD-1++ CD4+ T cells increased after birth and were abundant in infant intestines, resulting in significant higher numbers compared to adults. These findings were supported by scRNAseq analyses, showing increased frequencies of CD4+ T cells with a TFH gene signature in infant intestines compared to blood. Co-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+ T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B cells. Taken together, we demonstrate that functional TFH cells are numerous in infant intestines, making them a promising target for oral pediatric vaccine strategies.
536 _ _ |a 899 - ohne Topic (POF4-899)
|0 G:(DE-HGF)POF4-899
|c POF4-899
|f POF IV
|x 0
588 _ _ |a Dataset connected to DataCite
693 _ _ |0 EXP:(DE-MLZ)NOSPEC-20140101
|5 EXP:(DE-MLZ)NOSPEC-20140101
|e No specific instrument
|x 0
700 1 _ |a Martrus, Glòria
|b 1
700 1 _ |a Steinert, Fenja L.
|b 2
700 1 _ |a Kaufmann, Max
|b 3
700 1 _ |a Sagebiel, Adrian F.
|b 4
700 1 _ |a Schreurs, Renée R. C. E.
|b 5
700 1 _ |a Rechtien, Anne
|b 6
700 1 _ |a Baumdick, Martin E.
|0 0000-0001-5948-8109
|b 7
700 1 _ |a Jung, Johannes M.
|b 8
700 1 _ |a Möller, Kimberly J.
|0 0000-0003-2254-3025
|b 9
700 1 _ |a Wegner, Lucy
|b 10
700 1 _ |a Grüttner, Cordula
|b 11
700 1 _ |a Richert, Laura
|b 12
700 1 _ |a Thünauer, Roland
|0 P:(DE-H253)PIP1087856
|b 13
700 1 _ |a Schroeder-Schwarz, Jennifer
|b 14
700 1 _ |a van Goudoever, Johannes B.
|b 15
700 1 _ |a Geijtenbeek, Teunis B. H.
|b 16
700 1 _ |a Altfeld, Marcus
|b 17
700 1 _ |a Pals, Steven T.
|b 18
700 1 _ |a Perez, Daniel
|b 19
700 1 _ |a Klarenbeek, Paul L.
|b 20
700 1 _ |a Tomuschat, Christian
|b 21
700 1 _ |a Sauter, Guido
|b 22
700 1 _ |a Königs, Ingo
|b 23
700 1 _ |a Schumacher, Udo
|b 24
700 1 _ |a Friese, Manuel A.
|b 25
700 1 _ |a Melling, Nathaniel
|b 26
700 1 _ |a Reinshagen, Konrad
|b 27
700 1 _ |a Bunders, Madeleine J.
|0 P:(DE-HGF)0
|b 28
|e Corresponding author
773 _ _ |a 10.1038/s41423-022-00944-4
|g Vol. 20, no. 2, p. 201 - 213
|0 PERI:(DE-600)2219471-X
|n 2
|p 201 - 213
|t Cellular & molecular immunology
|v 20
|y 2023
|x 1672-7681
856 4 _ |u https://bib-pubdb1.desy.de/record/614230/files/s41423-022-00944-4.pdf
|y Restricted
856 4 _ |u https://bib-pubdb1.desy.de/record/614230/files/s41423-022-00944-4.pdf?subformat=pdfa
|x pdfa
|y Restricted
909 C O |o oai:bib-pubdb1.desy.de:614230
|p VDB
910 1 _ |a Centre for Structural Systems Biology
|0 I:(DE-H253)_CSSB-20140311
|k CSSB
|b 13
|6 P:(DE-H253)PIP1087856
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 13
|6 P:(DE-H253)PIP1087856
913 1 _ |a DE-HGF
|b Programmungebundene Forschung
|l ohne Programm
|1 G:(DE-HGF)POF4-890
|0 G:(DE-HGF)POF4-899
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-800
|4 G:(DE-HGF)POF
|v ohne Topic
|x 0
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2023-08-25
|w ger
915 _ _ |a DEAL Springer
|0 StatID:(DE-HGF)3002
|2 StatID
|d 2023-08-25
|w ger
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b CELL MOL IMMUNOL : 2022
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2023-08-25
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2023-08-25
915 _ _ |a IF >= 20
|0 StatID:(DE-HGF)9920
|2 StatID
|b CELL MOL IMMUNOL : 2022
|d 2023-08-25
920 1 _ |0 I:(DE-H253)CSSB-CF-ALFM-20210629
|k CSSB-CF-ALFM
|l CSSB-CF-ALFM
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-H253)CSSB-CF-ALFM-20210629
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21