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AQUACHIRAL

Chiral aqueous-phase chemistry

Grant period2021-01-01 - 2025-12-31
Funding bodyEuropean Union
Call numberERC-2019-ADG
Grant number883759
IdentifierG:(EU-Grant)883759

Note: Most chemical reactions in lifeforms take place in aqueous environments and probing biochemical molecules and their reactions in the aqueous phase is indispensable for advancing fundamental and applied science. Equally, intermolecular effects involving chiral complexes are highly relevant to life sciences, where hydration and chiral recognition are fundamental biochemical processes, typically occurring at aqueous interfaces. All of these processes are driven by electronic structure interactions with water molecules and are intimately connected with aqueous-phase electron binding energies. The prime experimental tool to access these properties is photoelectron spectroscopy (PES). With the recent invention of liquid-microjet-(LJ) PES, compatible with highly volatile liquid water and aqueous solutions, this technique has significantly contributed to modern water research, providing important insights into formerly elusive water properties, such as absolute energetics and solute interfacial distributions. I propose to explore chirality in aqueous solution using a novel aspect of photoelectron emission: photoelectron circular dichroism (PECD). It is site-specific and sensitive to chemical environment and structure. Furthermore, PECD exceeds absorption-based chiroptical signals by orders of magnitude, allowing application to dilute samples, potentially including interfacial layers, akin to PES. PECD has been demonstrated for isolated chiral molecules and clusters, and measurement of PECD effects in aqueous solution would mark a scientific breakthrough. The aim of AQUACHIRAL is to combine LJ-PES with PECD to (1) probe aqueous-phase chirality using enantioselective electronic-structure fingerprints of solutes and to (2) follow the stereochemistry of prominent chemical reactions in aqueous solution, e.g. slow glucose mutarotation. To achieve this, experimental technology must be extended, with novel liquid jets and electron detection systems being developed and optimized.
   

Recent Publications

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Site- and Energy-Selective Low-Energy Electron Emission by X-rays in the Aqueous Phase
Journal of the American Chemical Society 147(25), 22115 - 22120 () [10.1021/jacs.5c06436]  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Low-Energy Photoelectron Spectroscopy and Scattering from Aqueous Solutions and the Role of Solute Surface Activity
Journal of the American Chemical Society 147(23), 19868 - 19877 () [10.1021/jacs.5c04263]  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Photoelectron circular dichroism of aqueous-phase alanine
Chemical science 16(20), 8637 - 8647 () [10.1039/D5SC00167F]  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Boosting aerosol surface effects: strongly enhanced cooperative surface propensity of atmospherically relevant organic molecular ions in aqueous solution
Atmospheric chemistry and physics 25(6), 3503 - 3518 () [10.5194/acp-25-3503-2025]  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Interaction of ions and surfactants at the seawater–air interface
Environmental science / Atmospheres 5(3), 291 - 299 () [10.1039/D4EA00151F] special issue: "Brilliant Light Sources"  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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How Does $Mg^{2+}_{(aq)}$ Interact with $ATP_{(aq)}$? Biomolecular Structure through the Lens of Liquid-Jet Photoemission Spectroscopy
Journal of the American Chemical Society 146(23), 16062-16075 () [10.1021/jacs.4c03174]  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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From Gas to Solution: The Changing Neutral Structure of Proline upon Solvation
The journal of physical chemistry / A 128(47), 10202-10212 () [10.1021/acs.jpca.4c05628] special issue: "Richard J. Saykally Festschrift"  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Attosecond formation of charge-transfer-to-solvent states of aqueous ions probed using the core-hole-clock technique
Nature Communications 15(1), 8903 () [10.1038/s41467-024-52740-5]  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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The solvation shell probed by resonant intermolecular Coulombic decay
Nature Communications 15(1), 6926 () [10.1038/s41467-024-51417-3]  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Liquid-jet photoemission spectroscopy as a structural tool: site-specific acid–base chemistry of vitamin C
Physical chemistry, chemical physics 26(29), 19673-19684 () [10.1039/D4CP01521E]  GO OpenAccess  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

All known publications ...
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 Record created 2021-10-11, last modified 2023-02-12
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