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@ARTICLE{Stemer:628961,
      author       = {Stemer, Dominik and Thuermer, Stephan and Trinter, Florian
                      and Hergenhahn, Uwe and Pugini, Michele and Credidio, Bruno
                      and Malerz, Sebastian and Wilkinson, Iain and Nahon, Laurent
                      and Meijer, Gerard and Powis, Ivan and Winter, Bernd},
      title        = {{P}hotoelectron circular dichroism of aqueous-phase
                      alanine},
      journal      = {Chemical science},
      volume       = {16},
      number       = {20},
      issn         = {2041-6520},
      address      = {Cambridge},
      publisher    = {RSC},
      reportid     = {PUBDB-2025-01764},
      pages        = {8637 - 8647},
      year         = {2025},
      abstract     = {Amino acids and other small chiral molecules play key roles
                      in biochemistry. However, in order to understand how these
                      molecules behave in vivo, it is necessary to study them
                      under aqueous-phase conditions. Photoelectron circular
                      dichroism (PECD) has emerged as an extremely sensitive probe
                      of chiral molecules, but its suitability for application to
                      aqueous solutions had not yet been proven. Here, we report
                      on our PECD measurements of aqueous-phase alanine, the
                      simplest chiral amino acid. We demonstrate that the PECD
                      response of alanine in water is different for each of
                      alanine's carbon atoms, and is sensitive to molecular
                      structure changes (protonation states) related to the
                      solution pH. For C 1s photoionization of alanine's
                      carboxylic acid group, we report PECD of comparable
                      magnitude to that observed in valence-band photoelectron
                      spectroscopy of gas-phase alanine. We identify key
                      differences between PECD experiments from liquids and gases,
                      discuss how PECD may provide information regarding
                      solution-specific phenomena — for example the nature and
                      chirality of the solvation shell surrounding chiral
                      molecules in water — and highlight liquid-phase PECD as a
                      powerful new tool for the study of aqueous-phase chiral
                      molecules of biological relevance.},
      cin          = {DOOR ; HAS-User / FS-PETRA-S},
      ddc          = {540},
      cid          = {I:(DE-H253)HAS-User-20120731 /
                      I:(DE-H253)FS-PETRA-S-20210408},
      pnm          = {631 - Matter – Dynamics, Mechanisms and Control
                      (POF4-631) / 6G3 - PETRA III (DESY) (POF4-6G3) / DFG project
                      G:(GEPRIS)509471550 - Dynamik photoionisations-induzierter
                      Prozesse in laser-präparierten Molekülen in der Gasphase
                      und der wässrigen Phase (509471550) / AQUACHIRAL - Chiral
                      aqueous-phase chemistry (883759) / FS-Proposal: II-20180012
                      (II-20180012) / FS-Proposal: I-20200682 (I-20200682) /
                      FS-Proposal: I-20211126 (I-20211126) / FS-Proposal:
                      I-20230378 (I-20230378)},
      pid          = {G:(DE-HGF)POF4-631 / G:(DE-HGF)POF4-6G3 /
                      G:(GEPRIS)509471550 / G:(EU-Grant)883759 /
                      G:(DE-H253)II-20180012 / G:(DE-H253)I-20200682 /
                      G:(DE-H253)I-20211126 / G:(DE-H253)I-20230378},
      experiment   = {EXP:(DE-H253)P-P04-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40255964},
      UT           = {WOS:001468661800001},
      doi          = {10.1039/D5SC00167F},
      url          = {https://bib-pubdb1.desy.de/record/628961},
}