Journal Article

PUBDB-2024-00473

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multifunctional Cellulose Nanofibrils–GdF$_3$ Nanoparticles Hybrid Gel and Its Potential Uses for Drug Delivery and Magnetic Resonance Imaging

Jiang, X.Extern* ; Mietner, J. B. ; Raveendran, D.Extern* ; Ovchinnikov, K. V. ; Sochor, B.DESY* ; Mueller, S.Extern* ; Boehm-Sturm, P. ; Lerouge, F. ; Chaput, F. ; Gurikov, P. ; Roth, S. V.XFEL.EU*DESY* ; Navarro, J. R. G. (Corresponding author)Extern*

2023
ACS Publications Washington, DC

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Please use a persistent id in citations: doi:10.1021/acsanm.3c04272

Abstract: A multifunctional hybrid gel based on cellulose nanofibrils (CNFs) was developed by grafting on its surface stearyl acrylate (PSA) and gadolinium(III) fluoride nanoparticles (GdF$_3$ NPs) via Cu$^{0}$-mediated surface-initiated radical polymerization (SET-LRP) while encapsulating antimicrobial peptides in it. GdF$_3$ NPs were first surface-modified with 11-phosphonoundecyl acrylate (PDA) to participate in the SET-LRP and cross-linked the grafted polymer-modified CNF. Several characterizations of the hybrid material (GdF$_3$–PSA-CNF) were carried out, such as Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), rheology, and microscopic analyses. The grafted PSA and cross-linked GdF$_3$ NPs created sophisticated networks in the CNF-based gel, presenting outstanding rheological properties and promising three-dimensional (3D) printability of this hybrid material (GdF$_3$–PSA-CNF). The nanostructures of GdF$_3$ NPs and their incorporated CNF species were characterized via small-angle X-ray scattering (SAXS). In addition, due to the unique intrinsic property of the GdF$_3$ nanoparticles, properties for magnetic resonance imaging (MRI) of GdF$_3$–PSA-CNF were investigated, showing the potential application as a contrast agent. Finally, the encapsulation of the antimicrobial peptides added another function to the hybrid material, evaluated by an antimicrobial test against methicillin-resistant Staphylococcus aureus (MRSA) in vitro.

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)
2. Experimentebetreuung PETRA III (FS-PET-D)
3. Sustainable Materials (FS-SMA)

Research Program(s):

1. 632 - Materials – Quantum, Complex and Functional Materials (POF4-632) (POF4-632)
2. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
3. DFG project 390688087 - EXC 2049: Comprehensive approaches to neurological and psychiatric disorders "NeuroCure" (390688087) (390688087)

Experiment(s):

1. PETRA Beamline P03 (PETRA III)

Appears in the scientific report 2023

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Engineering, Computing and Technology ; Current Contents - Physical, Chemical and Earth Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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