%0 Journal Article
%A Jiang, Xuehe
%A Mietner, J. Benedikt
%A Raveendran, Dhanya
%A Ovchinnikov, Kirill V.
%A Sochor, Benedikt
%A Mueller, Susanne
%A Boehm-Sturm, Philipp
%A Lerouge, Frédéric
%A Chaput, Frédéric
%A Gurikov, Pavel
%A Roth, Stephan V.
%A Navarro, Julien R.G.
%T Multifunctional Cellulose Nanofibrils–GdF<sub>3</sub> Nanoparticles Hybrid Gel and Its Potential Uses for Drug Delivery and Magnetic Resonance Imaging
%J ACS applied nano materials
%V 6
%N 22
%@ 2574-0970
%C Washington, DC
%I ACS Publications
%M PUBDB-2024-00473
%P 21182 - 21193
%D 2023
%Z Waiting for fulltext
%X A multifunctional hybrid gel based on cellulose nanofibrils (CNFs) was developed by grafting on its surface stearyl acrylate (PSA) and gadolinium(III) fluoride nanoparticles (GdF<sub>3</sub> NPs) via Cu<sup>0</sup>-mediated surface-initiated radical polymerization (SET-LRP) while encapsulating antimicrobial peptides in it. GdF<sub>3</sub> NPs were first surface-modified with 11-phosphonoundecyl acrylate (PDA) to participate in the SET-LRP and cross-linked the grafted polymer-modified CNF. Several characterizations of the hybrid material (GdF<sub>3</sub>–PSA-CNF) were carried out, such as Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), rheology, and microscopic analyses. The grafted PSA and cross-linked GdF<sub>3</sub> NPs created sophisticated networks in the CNF-based gel, presenting outstanding rheological properties and promising three-dimensional (3D) printability of this hybrid material (GdF<sub>3</sub>–PSA-CNF). The nanostructures of GdF<sub>3</sub> NPs and their incorporated CNF species were characterized via small-angle X-ray scattering (SAXS). In addition, due to the unique intrinsic property of the GdF<sub>3</sub> nanoparticles, properties for magnetic resonance imaging (MRI) of GdF<sub>3</sub>–PSA-CNF were investigated, showing the potential application as a contrast agent. Finally, the encapsulation of the antimicrobial peptides added another function to the hybrid material, evaluated by an antimicrobial test against methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:001109825100001
%R 10.1021/acsanm.3c04272
%U https://bib-pubdb1.desy.de/record/602025