TY  - JOUR
AU  - Jiang, Xuehe
AU  - Mietner, J. Benedikt
AU  - Raveendran, Dhanya
AU  - Ovchinnikov, Kirill V.
AU  - Sochor, Benedikt
AU  - Mueller, Susanne
AU  - Boehm-Sturm, Philipp
AU  - Lerouge, Frédéric
AU  - Chaput, Frédéric
AU  - Gurikov, Pavel
AU  - Roth, Stephan V.
AU  - Navarro, Julien R.G.
TI  - Multifunctional Cellulose Nanofibrils–GdF<sub>3</sub> Nanoparticles Hybrid Gel and Its Potential Uses for Drug Delivery and Magnetic Resonance Imaging
JO  - ACS applied nano materials
VL  - 6
IS  - 22
SN  - 2574-0970
CY  - Washington, DC
PB  - ACS Publications
M1  - PUBDB-2024-00473
SP  - 21182 - 21193
PY  - 2023
N1  - Waiting for fulltext
AB  - A multifunctional hybrid gel based on cellulose nanofibrils (CNFs) was developed by grafting on its surface stearyl acrylate (PSA) and gadolinium(III) fluoride nanoparticles (GdF<sub>3</sub> NPs) via Cu<sup>0</sup>-mediated surface-initiated radical polymerization (SET-LRP) while encapsulating antimicrobial peptides in it. GdF<sub>3</sub> NPs were first surface-modified with 11-phosphonoundecyl acrylate (PDA) to participate in the SET-LRP and cross-linked the grafted polymer-modified CNF. Several characterizations of the hybrid material (GdF<sub>3</sub>–PSA-CNF) were carried out, such as Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), rheology, and microscopic analyses. The grafted PSA and cross-linked GdF<sub>3</sub> NPs created sophisticated networks in the CNF-based gel, presenting outstanding rheological properties and promising three-dimensional (3D) printability of this hybrid material (GdF<sub>3</sub>–PSA-CNF). The nanostructures of GdF<sub>3</sub> NPs and their incorporated CNF species were characterized via small-angle X-ray scattering (SAXS). In addition, due to the unique intrinsic property of the GdF<sub>3</sub> nanoparticles, properties for magnetic resonance imaging (MRI) of GdF<sub>3</sub>–PSA-CNF were investigated, showing the potential application as a contrast agent. Finally, the encapsulation of the antimicrobial peptides added another function to the hybrid material, evaluated by an antimicrobial test against methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:001109825100001
DO  - DOI:10.1021/acsanm.3c04272
UR  - https://bib-pubdb1.desy.de/record/602025
ER  -