Journal Article

PUBDB-2023-06638

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Sonogashira Coupling on Palladium Milling Balls—A new Reaction Pathway in Mechanochemistry

Pickhardt, W.Extern* ; Siegfried, E. ; Fabig, S.Extern* ; Rappen, M. F.Extern* ; Etter, M.DESY* ; Wohlgemuth, M.Extern* ; Grätz, S.Extern* ; Borchardt, L. (Corresponding author)

2023
Wiley-VCH Weinheim

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Please use a persistent id in citations: doi:10.1002/anie.202301490  doi:10.3204/PUBDB-2023-06638

Abstract: Utilizing direct mechanocatalytical conditions, the Sonogashira coupling was successfully performed on the surface of milling tools by using pure Pd and Pd coated steel balls. The optimization of co-catalyst forming additives led to a protocol, which generates quantitative yields under aerobic conditions for various substrates within as little as 90 minutes. Using state-of-the-art spectroscopic, diffractive, as well as in situ methods lead to the identification of a previously unknown and highly reactive complex of the co-catalyst copper. This new complex differs substantially from the known complexes in liquid phase Sonogashira couplings, proving that reaction pathways in mechanochemistry may differ from those in established synthetic procedures.

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)
2. PETRA-D (FS-PETRA-D)

Research Program(s):

1. 631 - Matter – Dynamics, Mechanisms and Control (POF4-631) (POF4-631)
2. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)

Experiment(s):

1. PETRA Beamline P02.1 (PETRA III)

Appears in the scientific report 2023

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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