TY  - JOUR
AU  - Pickhardt, Wilm
AU  - Siegfried, Eleonora
AU  - Fabig, Sven
AU  - Rappen, Marisol Fabienne
AU  - Etter, Martin
AU  - Wohlgemuth, Maximilian
AU  - Grätz, Sven
AU  - Borchardt, Lars
TI  - The Sonogashira Coupling on Palladium Milling Balls—A new Reaction Pathway in Mechanochemistry
JO  - Angewandte Chemie
VL  - 62
IS  - 27
SN  - 1433-7851
CY  - Weinheim
PB  - Wiley-VCH
M1  - PUBDB-2023-06638
SP  - e202301490
PY  - 2023
AB  - Utilizing direct mechanocatalytical conditions, the Sonogashira coupling was successfully performed on the surface of milling tools by using pure Pd and Pd coated steel balls. The optimization of co-catalyst forming additives led to a protocol, which generates quantitative yields under aerobic conditions for various substrates within as little as 90 minutes. Using state-of-the-art spectroscopic, diffractive, as well as in situ methods lead to the identification of a previously unknown and highly reactive complex of the co-catalyst copper. This new complex differs substantially from the known complexes in liquid phase Sonogashira couplings, proving that reaction pathways in mechanochemistry may differ from those in established synthetic procedures. 
LB  - PUB:(DE-HGF)16
C6  - 37018656
UR  - <Go to ISI:>//WOS:000994540100001
DO  - DOI:10.1002/anie.202301490
UR  - https://bib-pubdb1.desy.de/record/597643
ER  -