%0 Journal Article
%A Pickhardt, Wilm
%A Siegfried, Eleonora
%A Fabig, Sven
%A Rappen, Marisol Fabienne
%A Etter, Martin
%A Wohlgemuth, Maximilian
%A Grätz, Sven
%A Borchardt, Lars
%T The Sonogashira Coupling on Palladium Milling Balls—A new Reaction Pathway in Mechanochemistry
%J Angewandte Chemie
%V 62
%N 27
%@ 1433-7851
%C Weinheim
%I Wiley-VCH
%M PUBDB-2023-06638
%P e202301490
%D 2023
%X Utilizing direct mechanocatalytical conditions, the Sonogashira coupling was successfully performed on the surface of milling tools by using pure Pd and Pd coated steel balls. The optimization of co-catalyst forming additives led to a protocol, which generates quantitative yields under aerobic conditions for various substrates within as little as 90 minutes. Using state-of-the-art spectroscopic, diffractive, as well as in situ methods lead to the identification of a previously unknown and highly reactive complex of the co-catalyst copper. This new complex differs substantially from the known complexes in liquid phase Sonogashira couplings, proving that reaction pathways in mechanochemistry may differ from those in established synthetic procedures. 
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 37018656
%U <Go to ISI:>//WOS:000994540100001
%R 10.1002/anie.202301490
%U https://bib-pubdb1.desy.de/record/597643