OpenAccess

The QCD/HQET matching coefficient for the heavy-quark field is calculated up to four loops. It must be finite; this requirement produces analytical results for some terms in the four-loop on-shell heavy-quark field renormalization constant which were previously only known numerically. [...]

Bruton’s tyrosine kinase (Btk) is critical for B-cell maturation and activation. Btk loss-of-function mutations cause human X-linked agammaglobulinemia (XLA) [...]

This article presents IMSIM, an application to simulate two-dimensional small-angle X-ray scattering patterns and, further, one-dimensional profiles from biological macromolecules in solution. IMSIM implements a statistical approach yielding two-dimensional images in TIFF, CBF or EDF format, which may be readily processed by existing data-analysis pipelines [...]

The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system. We investigate the possible interaction and the interaction mechanism of a polymeric drug delivery system based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA) with the most abundant proteins in human blood plasma—namely, human serum albumin (HSA), immunoglobulin G (IgG), fibrinogen (Fbg), and apolipoprotein (Apo) E4 and A1—using a combination of small-angle X-ray scattering (SAXS), analytical ultracentrifugation (AUC), and nuclear magnetic resonance (NMR) [...]

The spontaneous breaking of U(1)$_{B−L}$ around the scale of grand unification can simultaneously account for hybrid inflation, leptogenesis, and neutralino dark matter, thus resolving three major puzzles of particle physics and cosmology in a single predictive framework. The $B−L$ phase transition also results in a network of cosmic strings. [...]

Small‐angle scattering (SAS) of X‐rays and neutrons is a fundamental tool to study the nanostructural properties, and in particular, biological macromolecules in solution. In structural biology, SAS recently transformed from a specialization into a general technique leading to a dramatic increase in the number of publications reporting structural models [...]

The mammalian CLOCK:BMAL1 transcription factor complex and its coactivators CREB-binding protein (CBP)/p300 and mixed-lineage leukemia 1 (MLL1) play a central role in circadian transcriptional regulation and chromatin modification. The interactions of BMAL1’s C-terminal transactivation domain (TAD) with the KIX domain of CBP/p300 (activating) and with CRY1 (repressing) as well as the BMAL1 G-region preceding the TAD regulate the circadian oscillations [...]

Permanganate aqueous solutions, MnO$_4$$^-$(aq.), were studied using liquid-micro-jet-based soft X-ray non-resonant and resonant photoelectron spectroscopy to determine valence and core-level binding energies. To identify possible differences in the energetics between the aqueous bulk and the solution-gas interface, non-resonant spectra were recorded at two different probing depths. [...]

Minerals formed at high pressures are sensitive indicators of extreme pressure-temperature conditions that occur in nature. The discovery of the high-pressure polymorph of (Fe,Ni)$_2$P, allabogdanite in the surficial pyrometamorphic rocks of the Hatrurim Formation (the Mottled Zone) surrounding the Dead Sea basin in Israel is the first terrestrial occurrence of a mineral previously only found in iron meteorites. [...]