OpenAccess

Medicinal‐chemistry optimization follows strategies replacing functional groups and attaching larger substituents at a promising lead scaffold. Well‐established bioisosterism rules are considered, however, it is difficult to estimate whether the introduced modifications really match the required properties at a binding site. [...]

PSD-95 is a member of the membrane-associated guanylate kinase class of proteins that forms scaffolding interactions with partner proteins, including ion and receptor channels. PSD-95 is directly implicated in modulating the electrical responses of excitable cells. [...]

A new baryon state is observed in the $ {\Lambda}_{\mathrm{b}}^0{\pi}^{+}{\pi}^{-} $ mass spectrum with high significance using a data sample of pp collisions, collected with the LHCb detector at centre-of-mass energies $ \sqrt{s} $ = 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb$^{−1}$. The mass and natural width of the new state are measured to be$ {\displaystyle \begin{array}{l}m=6072.3\pm 2.9\pm 0.6\pm 0.2\ \mathrm{MeV},\\ {}\Gamma =72\pm 11\pm 2\ \mathrm{MeV},\end{array}} $where the first uncertainty is statistical and the second systematic [...]

A first search for $CP$ violation in the Cabibbo-suppressed ${{{\varXi }} ^+_{c}} \rightarrow {p} {{K} ^-} {{\pi } ^+} $ decay is performed using both a binned and an unbinned model-independent technique in the Dalitz plot. The studies are based on a sample of proton-proton collision data, corresponding to an integrated luminosity of $3.0\,\text {fb} ^{-1} $, and collected by the LHCb experiment at centre-of-mass energies of 7 and $8\,\text {TeV} $. [...]

Using a data sample corresponding to an integrated luminosity of 2.0 $\, \text {fb} ^{-1}$, collected by the LHCb experiment, the production of the ${\eta _{c}} (1S)$ state in proton–proton collisions at a centre-of-mass energy of $\sqrt{s} =13\, \text {TeV}$ is studied in the rapidity range $2.0< y < 4.5$ and in the transverse momentum range $6.5< p_{\mathrm {T}} < 14.0 \, \text {GeV} $. The cross-section for prompt production of ${\eta _{c}} (1S)$ mesons relative to that of the ${J /\psi }$ meson is measured using the $p \overline{{p}}$ decay mode and is found to be ${\sigma _{{\eta _{c}} (1S)}/\sigma _{{{J /\psi }}} = 1.69 \pm 0.15 \pm 0.10 \pm 0.18}$. [...]

An angular analysis of the B$^{0}$ → K*$^{0}$e$^{+}$e$^{−}$ decay is performed using a data sample corresponding to an integrated luminosity of 9 fb$^{−1}$ of pp collisions collected with the LHCb experiment. The analysis is conducted in the very low dielectron mass squared (q$^{2}$) interval between 0.0008 and 0.257 GeV$^{2}$, where the rate is dominated by the B$^{0}$ → K$^{*0}$γ transition with a virtual photon. [...]

We report the V-assisted synthesis of Na$_2$Ti$_3$O$_7$ nanorods via a conventional solid state reaction technique. Energy dispersive X-ray spectroscopy (EDS) mapping showed that V-ions are not incorporated into the main structure of the nanorods but rather V behaves as a flux agent during the growth of the nanorods. [...]

The relative branching fractions of $B^+ \to h^+h^{\prime +}h^{\prime -}$ decays, where $h^{(\prime)}$ is a pion or kaon, are measured. The analysis is performed with a data sample, collected with the LHCb detector, corresponding to an integrated luminosity of $3.0 {\rm fb}^{-1}$ of $pp$ collisions. [...]

The $\Xi_c^0$ baryon is unstable and usually decays into charmless final states by the $c→su{\overline{d}}$ transition. It can, however, also disintegrate into a $π^−$ meson and a $Λ^+_c$ baryon via $s$ quark decay or via $cs→dc$ weak scattering [...]