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Journal Article PUBDB-2018-03102
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Megahertz serial crystallography

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2018
Nature Publishing Group London

Nature Communications 9(1), 4025 () [10.1038/s41467-018-06156-7]
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Abstract: The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.

Classification:
Contributing Institute(s):
  1. FS-CFEL-1 (Group Leader: Henry Chapman) (CFEL-I)
  2. European XFEL Projekt Team (Eur.XFEL)
  3. FS-ML (CFEL-XOM)
  4. FS-Photon Science (FS-PS)
  5. Controlled Molecule Imaging (FS-CFEL-CMI)
  6. FS-DS (CFEL-DRD)
  7. FS-CFEL-2 (CFEL-UFOX)
  8. Strukturdynamik Chemischer Systeme (FS-SCS)
Research Program(s):
  1. 6215 - Soft Matter, Health and Life Sciences (POF3-621) (POF3-621)
  2. AXSIS - Frontiers in Attosecond X-ray Science: Imaging and Spectroscopy (609920) (609920)
  3. 05K13GU7 - Test eines "Serial Femtosecond Crystallography (SFX)"-Messtandes am Europäischen Elektronenlaser XFEL (BMBF-05K13GU7) (BMBF-05K13GU7)
  4. Leibniz Preis - Leibiz Programm 2015: Prof. Dr. Henry N. Chapman (DFG-Leibniz-2015-Chapman) (DFG-Leibniz-2015-Chapman)
  5. COMOTION - Controlling the Motion of Complex Molecules and Particles (614507) (614507)
  6. Ex-Net-0002-Phase2-3 - Advanced Imaging of Matter: Structure, Dynamics and Control on the Atomic Scale - AIM (2018_Ex-Net-0002-Phase2-3) (2018_Ex-Net-0002-Phase2-3)
  7. HRSF-0002 - New avenues in information and data science: advanced imaging applications at the XFEL and cryo-EM frontier (2018_HRSF-0002) (2018_HRSF-0002)
  8. IVF - Impuls- und Vernetzungsfonds (IVF-20140101) (IVF-20140101)
  9. 05E13GU1 - Entwicklung eines "Serial Femtosecond Crystallography (SFX)"-Messtandes am Europäischen Elektronenlaser XFEL (BMBF-05E13GU1) (BMBF-05E13GU1)
  10. CUI - Hamburger Zentrum für ultraschnelle Beobachtung (194651731) (194651731)
  11. 05K2014, SyncFELmed - Verbundprojekt 05K2014 (BMBF-05K2014) (BMBF-05K2014)
  12. X-probe - Advanced XFEL and Synchrotron based Probes of Protein Structure and Dynamics (637295) (637295)
Experiment(s):
  1. Experiments at XFEL
  2. Experiments at CFEL

Appears in the scientific report 2018
Database coverage:
Medline ; Creative Commons Attribution CC BY 4.0 ; DOAJ ; OpenAccess ; BIOSIS Previews ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record
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The record appears in these collections:
Private Collections > >CFEL > >FS-CFEL > CFEL-UFOX
Private Collections > >CFEL > >FS-CFEL > CFEL-XOM
Private Collections > >CFEL > >FS-CFEL > CFEL-DRD
Private Collections > >CFEL > >FS-CFEL > CFEL-I
Private Collections > >DESY > >FS > FS-CFEL-CMI
Private Collections > >DESY > >FS > FS-SCS
Private Collections > >DESY > >FS > FS-PS
Private Collections > >XFEL.EU > Eur.XFEL
Document types > Articles > Journal Article
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 Record created 2018-08-22, last modified 2025-07-17
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