Combining synchrotron and free electron laser infrastructures for applications in molecular medicine – creating novel synergies across borders and disciplinesSynchrotron und Freie-Elektronen-Laser Infrastrukturen für den kombinierten Einsatz in der Molekularen Medizin - Schaffung von neuartigen Synergien durch interdisziplinäre BrückenschlägeVerbundprojekt 05K2014
Coordinator
Chapman, Henry N. ; Wilmanns, Matthias ; Tonevitsky, Alexander ; Schumacher, Udo ; Schneider, Thomas ; Gabibov, Alexander
Note: Verbundprojekt 05K2014 – SyncFELmed is a Russian-German consortium of six partners (five full members and one associate member), funded by the the Federal Ministry of Education and Research (BMBF) and the Russian Ministry of Education and Science. Its aim is to advance combined synchrotron radiation and free electron laser technologies in biomedical sciences, for applications ranging from mechanistic research questions to clinical drug development.
Our focus is on interdisciplinary research and development as well as training and dissemination of emerging approaches, techniques and protocols to make the best possible use of the unprecedented opportunities presented by the unrivalled X-ray sources PETRA III and the X-FEL.
Four groups from Germany and two from Russia have joined forces to improve and expand the general methodology of serial crystallography, approaching the method from a combination of recent developments using FEL sources, recent implementations using synchrotron sources, and well-established crystallographic practices. In terms of biomedical applications, the consortium will cooperate with two leading experts from Russia who will exploit the structural data anticipated to emerge from using the infrastructures at PETRA III and X-FEL to address important biomedical research questions for which atomic resolution structural information will be essential. A third component of the consortium includes clinical research and applications, by the addition of a group from the University Medical Center Eppendorf (UKE), Hamburg, Germany.
Our consortium aims to paradigmatically demonstrate a win - win situation generated from research and development-oriented cooperation of research organizations involved in the provision of relevant infrastructures (DESY, EMBL), and possible recipients with interests ranging from mechanistic fundamental research to concrete clinical applications (RAC, Moscow; University of Hamburg; University Medical Center Eppendorf (UKE)).
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