%0 Journal Article
%A Wiedorn, Max O.
%A Oberthür, Dominik
%A Bean, Richard
%A Schubert, Robin
%A Werner, Nadine
%A Abbey, Brian
%A Aepfelbacher, Martin
%A Adriano, Luigi
%A Allahgholi, Aschkan
%A Al-Qudami, Nasser
%A Andreasson, Jakob
%A Aplin, Steve
%A Awel, Salah
%A Ayyer, Kartik
%A Bajt, Saša
%A Barak, Imrich
%A Bari, Sadia
%A Bielecki, Johan
%A Botha, Sabine
%A Boukhelef, Djelloul
%A Brehm, Wolfgang
%A Brockhauser, Sandor
%A Cheviakov, Igor
%A Coleman, Matthew A.
%A Cruz-Mazo, Francisco
%A Danilevski, Cyril
%A Darmanin, Connie
%A Doak, R. Bruce
%A Domaracky, Martin
%A Dörner, Katerina
%A Du, Yang
%A Fangohr, Hans
%A Fleckenstein, Holger
%A Frank, Matthias
%A Fromme, Petra
%A Ganan-Calvo, Alfonso
%A Gevorkov, Yaroslav
%A Giewekemeyer, Klaus
%A Ginn, Helen
%A Graafsma, Heinz
%A Graceffa, Rita
%A Greiffenberg, Dominic
%A Gumprecht, Lars
%A Göttlicher, Peter
%A Hajdu, Janos
%A Hauf, Steffen
%A Heymann, Michael
%A Holmes, Susannah
%A Horke, Daniel A.
%A Hunter, Mark S.
%A Imlau, Siegfried
%A Kaukher, Alexander
%A Kim, Yoonhee
%A Klyuev, Alexander
%A Knoska, Juraj
%A Kobe, Bostjan
%A Kuhn, Manuela
%A Kupitz, Christopher
%A Küpper, Jochen
%A Lahey-Rudolph, Janine Mia
%A Laurus, Torsten
%A Le Cong, Karoline
%A Letrun, Romain
%A Xavier, P. Lourdu
%A Maia, Luis
%A Maia, Filipe R. N. C.
%A Mariani, Valerio
%A Messerschmidt, Marc
%A Metz, Markus
%A Mezza, Davide
%A Michelat, Thomas
%A Mills, Grant
%A Monteiro, Diana
%A Morgan, Andrew
%A Mühlig, Kerstin
%A Munke, Anna
%A Münnich, Astrid
%A Nette, Julia
%A Nugent, Keith
%A Nuguid, Theresa
%A Orville, Allen
%A Pandey, Suraj
%A Pena, Gisel
%A Villanueva-Perez, Pablo
%A Poehlsen, Jennifer
%A Previtali, Gianpietro
%A Redecke, Lars
%A Riekehr, Winnie Maria
%A Rohde, Holger
%A Round, Adam
%A Safenreiter, Tatiana
%A Sarrou, Iosifina
%A Sato, Tokushi
%A Schmidt, Marius
%A Schmitt, Bernd
%A Schönherr, Robert
%A Schulz, Joachim
%A Sellberg, Jonas
%A Seibert, M. Marvin
%A Seuring, Carolin
%A Shelby, Megan
%A Shoeman, Robert
%A Sikorski, Marcin
%A Silenzi, Alessandro
%A Stan, Claudiu
%A Shi, Xintian
%A Stern, Stephan
%A Sztuk-Dambietz, Jola
%A Szuba, Janusz
%A Tolstikova, Aleksandra
%A Trebbin, Martin
%A Trunk, Ulrich
%A Vagovic, Patrik
%A Ve, Thomas
%A Weinhausen, Britta
%A White, Thomas A.
%A Wrona, Krzysztof
%A Xu, Chen
%A Yefanov, Oleksandr
%A Zatsepin, Nadia
%A Zhang, Jiaguo
%A Perbandt, Markus
%A Mancuso, Adrian P.
%A Betzel, Christian
%A Chapman, Henry
%A Barty, Anton
%T Megahertz serial crystallography
%J Nature Communications
%V 9
%N 1
%@ 2041-1723
%C London
%I Nature Publishing Group
%M PUBDB-2018-03102
%P 4025
%D 2018
%X The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30279492
%U <Go to ISI:>//WOS:000446016400003
%R 10.1038/s41467-018-06156-7
%U https://bib-pubdb1.desy.de/record/408797