Journal Article

PUBDB-2025-02069

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Membrantransport von Thiamin im menschlichen Körper

Gabriel, F.Extern*CSSB*EMBL* ; Loew, C. (Corresponding author)CSSB*

2025
Springer Nature Heidelberg

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Please use a persistent id in citations: doi:10.1007/s12268-025-2462-4  doi:10.3204/PUBDB-2025-02069

Abstract: Thiamine (vitamin B$_1$) is an essential coenzyme for central metabolic pathways. Metazoans, including humans, have to take up thiamine via the solute carriers SLC19A2 and SLC19A3, because they lost the ability to synthesize thiamine de novo. Perturbation of these transport systems has severe effects on human health. Here we discuss the molecular mechanisms of thiamine recognition, transport and inhibition based on recently available cryo-Electron Microscopy structures of SLC19A3.

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Contributing Institute(s):

1. CSSB-EMBL-CL (CSSB-EMBL-CL)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Experiment(s):

1. No specific instrument

Appears in the scientific report 2025

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Database coverage:
; ; ; DEAL Springer ; SCOPUS

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