TY  - JOUR
AU  - Gabriel, Florian
AU  - Loew, Christian
TI  - Membrantransport von Thiamin im menschlichen Körper
JO  - Biospektrum
VL  - 31
IS  - 3
SN  - 0947-0867
CY  - Heidelberg
PB  - Springer Nature
M1  - PUBDB-2025-02069
SP  - 266 - 268
PY  - 2025
AB  - Thiamine (vitamin B<sub>1</sub>) is an essential coenzyme for central metabolic pathways. Metazoans, including humans, have to take up thiamine via the solute carriers SLC19A2 and SLC19A3, because they lost the ability to synthesize thiamine de novo. Perturbation of these transport systems has severe effects on human health. Here we discuss the molecular mechanisms of thiamine recognition, transport and inhibition based on recently available cryo-Electron Microscopy structures of SLC19A3.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1007/s12268-025-2462-4
UR  - https://bib-pubdb1.desy.de/record/631954
ER  -