Journal Article

PUBDB-2025-01098

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Interfacing with the Brain: How Nanotechnology Can Contribute

Ahmed, A. A. A. ; Alegret, N. ; Almeida, B. ; Alvarez-Puebla, R. ; Andrews, A. M. ; Ballerini, L. ; Barrios-Capuchino, J. J. ; Becker, C. ; Blick, R. H. ; Bonakdar, S. ; Chakraborty, I. ; Chen, X. ; Cheon, J. ; Chilla, G. ; Coelho Conceicao, A. L. ; Delehanty, J. ; Dulle, M. ; Efros, A. L. ; Epple, M. ; Fedyk, M. ; Feliu, N. ; Feng, M. ; Fernández-Chacón, R. ; Fernandez-Cuesta, I.Extern* ; Fertig, N. ; Förster, S. ; Garrido, J. A. ; George, M. ; Guse, A. H. ; Hampp, N. ; Harberts, J. ; Han, J. ; Heekeren, H. R. ; Hofmann, U. G. ; Holzapfel, M. ; Hosseinkazemi, H. ; Huang, Y. ; Huber, P. (Corresponding author)Extern*DESY* ; Hyeon, T. ; Ingebrandt, S. ; Ienca, M. ; Iske, A. ; Kang, Y. ; Kasieczka, G. ; Kim, D.-H. ; Kostarelos, K. ; Lee, J.-H. ; Lin, K.-W. ; Liu, S. ; Liu, X. ; Liu, Y. ; Lohr, C. ; Mailänder, V. ; Maffongelli, L. ; Megahed, S. ; Mews, A. ; Mutas, M. ; Nack, L. ; Nakatsuka, N. ; Oertner, T. G. ; Offenhäusser, A. ; Oheim, M. ; Otange, B. ; Otto, F. ; Patrono, E. ; Peng, B. ; Picchiotti, A. ; Pierini, F. ; Pötter-Nerger, M. ; Pozzi, M. ; Pralle, A. ; Prato, M. ; Qi, B. ; Ramos-Cabrer, P. ; Genger, U. R. ; Ritter, N. ; Rittner, M. ; Roy, S. ; Santoro, F. ; Schuck, N. W. ; Schulz, F. ; Şeker, E. ; Skiba, M. ; Sosniok, M. ; Stephan, H. ; Wang, R. ; Wang, T. ; Wegner, K. D. ; Weiss, P. S. ; Xu, M. ; Yang, C. ; Zargarian, S. S. ; Zeng, Y. ; Zhou, Y. ; Zhu, D. ; Zierold, R. ; Parak, W. J.

2025
Soc. Washington, DC

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Please use a persistent id in citations: doi:10.1021/acsnano.4c10525  doi:10.3204/PUBDB-2025-01098

Abstract: Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain–machine interfaces have changed over time, along with the available technology. Mechanical levers and cable winches were used to move parts of the brain during the mechanical age. Sophisticated electronic wiring and remote control have arisen during the electronic age, ultimately leading to plug-and-play computer interfaces. Nonetheless, our brains are so complex that these visions, until recently, largely remained unreachable dreams. The general problem, thus far, is that most of our technology is mechanically and/or electrically engineered, whereas the brain is a living, dynamic entity. As a result, these worlds are difficult to interface with one another. Nanotechnology, which encompasses engineered solid-state objects and integrated circuits, excels at small length scales of single to a few hundred nanometers and, thus, matches the sizes of biomolecules, biomolecular assemblies, and parts of cells. Consequently, we envision nanomaterials and nanotools as opportunities to interface with the brain in alternative ways. Here, we review the existing literature on the use of nanotechnology in brain–machine interfaces and look forward in discussing perspectives and limitations based on the authors’ expertise across a range of complementary disciplines─from neuroscience, engineering, physics, and chemistry to biology and medicine, computer science and mathematics, and social science and jurisprudence. We focus on nanotechnology but also include information from related fields when useful and complementary.

Note: R.G. received financial support by the German Research Council (DFG, grant RE 1203/38-1. SIREN)

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Contributing Institute(s):

1. CIMMS-RA Center for integr. Multiscale M (CIMMS)

Research Program(s):

1. 632 - Materials – Quantum, Complex and Functional Materials (POF4-632) (POF4-632)
2. DFG project G:(GEPRIS)509293944 - Wässrige Elektrolyte in nanoporösen Medien: Struktur, Dynamik und elektrochemomechanische Aktuation (509293944) (509293944)
3. GRK 2536 - GRK 2536: Hybridstrukturen auf der Nanometerskala: Chemische Konzepte zur Herstellung heterogener Nanostrukturen mit anisotropen Materialeigenschaften (NANOHYBRID) (408076438) (408076438)
4. AIM, DFG project G:(GEPRIS)390715994 - EXC 2056: CUI: Advanced Imaging of Matter (390715994) (390715994)
5. DFG project G:(GEPRIS)335447717 - SFB 1328: Adeninnukleotide in Immunität und Entzündung (335447717) (335447717)

Experiment(s):

1. No specific instrument

Appears in the scientific report 2025

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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