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@ARTICLE{Ahmed:625324,
author = {Ahmed, Abdullah A. A. and Alegret, Nuria and Almeida,
Bethany and Alvarez-Puebla, Ramón and Andrews, Anne M. and
Ballerini, Laura and Barrios-Capuchino, Juan J. and Becker,
Charline and Blick, Robert H. and Bonakdar, Shahin and
Chakraborty, Indranath and Chen, Xiaodong and Cheon, Jinwoo
and Chilla, Gerwin and Coelho Conceicao, Andre Luiz and
Delehanty, James and Dulle, Martin and Efros, Alexander L.
and Epple, Matthias and Fedyk, Mark and Feliu, Neus and
Feng, Miao and Fernández-Chacón, Rafael and
Fernandez-Cuesta, Irene and Fertig, Niels and Förster,
Stephan and Garrido, Jose A. and George, Michael and Guse,
Andreas H. and Hampp, Norbert and Harberts, Jann and Han,
Jili and Heekeren, Hauke R. and Hofmann, Ulrich G. and
Holzapfel, Malte and Hosseinkazemi, Hessam and Huang, Yalan
and Huber, Patrick and Hyeon, Taeghwan and Ingebrandt, Sven
and Ienca, Marcello and Iske, Armin and Kang, Yanan and
Kasieczka, Gregor and Kim, Dae-Hyeong and Kostarelos, Kostas
and Lee, Jae-Hyun and Lin, Kai-Wei and Liu, Sijin and Liu,
Xin and Liu, Yang and Lohr, Christian and Mailänder, Volker
and Maffongelli, Laura and Megahed, Saad and Mews, Alf and
Mutas, Marina and Nack, Leroy and Nakatsuka, Nako and
Oertner, Thomas G. and Offenhäusser, Andreas and Oheim,
Martin and Otange, Ben and Otto, Ferdinand and Patrono,
Enrico and Peng, Bo and Picchiotti, Alessandra and Pierini,
Filippo and Pötter-Nerger, Monika and Pozzi, Maria and
Pralle, Arnd and Prato, Maurizio and Qi, Bing and
Ramos-Cabrer, Pedro and Genger, Ute Resch and Ritter,
Norbert and Rittner, Marten and Roy, Sathi and Santoro,
Francesca and Schuck, Nicolas W. and Schulz, Florian and
Şeker, Erkin and Skiba, Marvin and Sosniok, Martin and
Stephan, Holger and Wang, Ruixia and Wang, Ting and Wegner,
K. David and Weiss, Paul S. and Xu, Ming and Yang, Chenxi
and Zargarian, Seyed Shahrooz and Zeng, Yuan and Zhou,
Yaofeng and Zhu, Dingcheng and Zierold, Robert and Parak,
Wolfgang J.},
title = {{I}nterfacing with the {B}rain: {H}ow {N}anotechnology
{C}an {C}ontribute},
journal = {ACS nano},
volume = {19},
number = {11},
issn = {1936-0851},
address = {Washington, DC},
publisher = {Soc.},
reportid = {PUBDB-2025-01098},
pages = {10630 - 10717},
year = {2025},
note = {R.G. received financial support by the German Research
Council (DFG, grant RE 1203/38-1. SIREN)},
abstract = {Interfacing artificial devices with the human brain is the
central goal of neurotechnology. Yet, our imaginations are
often limited by currently available paradigms and
technologies. Suggestions for brain–machine interfaces
have changed over time, along with the available technology.
Mechanical levers and cable winches were used to move parts
of the brain during the mechanical age. Sophisticated
electronic wiring and remote control have arisen during the
electronic age, ultimately leading to plug-and-play computer
interfaces. Nonetheless, our brains are so complex that
these visions, until recently, largely remained unreachable
dreams. The general problem, thus far, is that most of our
technology is mechanically and/or electrically engineered,
whereas the brain is a living, dynamic entity. As a result,
these worlds are difficult to interface with one another.
Nanotechnology, which encompasses engineered solid-state
objects and integrated circuits, excels at small length
scales of single to a few hundred nanometers and, thus,
matches the sizes of biomolecules, biomolecular assemblies,
and parts of cells. Consequently, we envision nanomaterials
and nanotools as opportunities to interface with the brain
in alternative ways. Here, we review the existing literature
on the use of nanotechnology in brain–machine interfaces
and look forward in discussing perspectives and limitations
based on the authors’ expertise across a range of
complementary disciplines─from neuroscience, engineering,
physics, and chemistry to biology and medicine, computer
science and mathematics, and social science and
jurisprudence. We focus on nanotechnology but also include
information from related fields when useful and
complementary.},
cin = {CIMMS},
ddc = {540},
cid = {I:(DE-H253)CIMMS-20211022},
pnm = {632 - Materials – Quantum, Complex and Functional
Materials (POF4-632) / DFG project G:(GEPRIS)509293944 -
Wässrige Elektrolyte in nanoporösen Medien: Struktur,
Dynamik und elektrochemomechanische Aktuation (509293944) /
GRK 2536 - GRK 2536: Hybridstrukturen auf der
Nanometerskala: Chemische Konzepte zur Herstellung
heterogener Nanostrukturen mit anisotropen
Materialeigenschaften (NANOHYBRID) (408076438) / AIM, DFG
project G:(GEPRIS)390715994 - EXC 2056: CUI: Advanced
Imaging of Matter (390715994) / DFG project
G:(GEPRIS)335447717 - SFB 1328: Adeninnukleotide in
Immunität und Entzündung (335447717)},
pid = {G:(DE-HGF)POF4-632 / G:(GEPRIS)509293944 /
G:(GEPRIS)408076438 / G:(GEPRIS)390715994 /
G:(GEPRIS)335447717},
experiment = {EXP:(DE-MLZ)NOSPEC-20140101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40063703},
UT = {WOS:001446202200001},
doi = {10.1021/acsnano.4c10525},
url = {https://bib-pubdb1.desy.de/record/625324},
}