Journal Article

PUBDB-2024-00574

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png AlphaPulldown—a python package for protein–protein interaction screens using AlphaFold-Multimer

Yu, D.Extern*CSSB* ; Chojnowski, G. ; Rosenthal, M. ; Kosinski, J. (Corresponding author)CSSB*

2023
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/bioinformatics/btac749  doi:10.3204/PUBDB-2024-00574

Abstract: The artificial intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein–protein interactions (PPIs). Here, we present AlphaPulldown, a Python package that streamlines PPI screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command-line interface, a variety of confidence scores and a graphical analysis tool.

Note: This work was supported by the German Research Foundation (DFG) [KO 5979/2-1].

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Contributing Institute(s):

1. CSSB-EMBL-JK (CSSB-EMBL-JK)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Experiment(s):

1. No specific instrument

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