Journal Article

PUBDB-2023-05209

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants

Sefa, S. (Corresponding author)Extern*HZG*Hereon* ; Espiritu, J. ; Ćwieka, H.Extern* ; Greving, I.HZG*Hereon* ; Flenner, S.Extern*HZG*Hereon* ; Will, O. ; Beuer, S. ; Wieland, D. C. F. ; Willumeit-Römer, R. ; Zeller-Plumhoff, B. (Corresponding author)HZG*Hereon*

2023
Elsevier B.V. [Amsterdam]

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Please use a persistent id in citations: doi:10.1016/j.bioactmat.2023.07.017  doi:10.3204/PUBDB-2023-05209

Abstract: The utilization of biodegradable magnesium (Mg)-based implants for restoration of bone function following trauma represents a transformative approach in orthopaedic application. One such alloy, magnesium-10 weight percent gadolinium (Mg-10Gd), has been specifically developed to address the rapid degradation of Mg while enhancing its mechanical properties to promote bone healing. Previous studies have demonstrated that Mg-10Gd exhibits favorable osseointegration; however, it exhibits distinct ultrastructural adaptation in comparison to conventional implants like titanium (Ti). A crucial aspect that remains unexplored is the impact of Mg-10Gd degradation on the bone microarchitecture. To address this, we employed hierarchical three-dimensional imaging using synchrotron radiation in conjunction with image-based finite element modelling. By using the methods outlined, the vascular porosity, lacunar porosity and the lacunar-canaliculi network (LCN) morphology of bone around Mg-10Gd in comparison to Ti in a rat model from 4 weeks to 20 weeks post-implantation was investigated. Our investigation revealed that within our observation period, the degradation of Mg-10Gd implants was associated with significantly lower (p < 0.05) lacunar density in the surrounding bone, compared to Ti. Remarkably, the LCN morphology and the fluid flow analysis did not significantly differ for both implant types. In summary, a more pronounced lower lacunae distribution rather than their morphological changes was detected in the surrounding bone upon the degradation of Mg-10Gd implants. This implies potential disparities in bone remodelling rates when compared to Ti implants. Our findings shed light on the intricate relationship between Mg-10Gd degradation and bone microarchitecture, contributing to a deeper understanding of the implications for successful osseointegration.

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Contributing Institute(s):

1. Helmholtz-Zentrum Hereon (Hereon)
2. DOOR-User (DOOR ; HAS-User)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)

Experiment(s):

1. PETRA Beamline P05 (PETRA III)

Appears in the scientific report 2023

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Database coverage:
; ; ; ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; IF >= 15 ; JCR ; PubMed Central ; SCOPUS ; Web of Science Core Collection

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