%0 Journal Article
%A Sefa, Sandra
%A Espiritu, Jonathan
%A Ćwieka, Hanna
%A Greving, Imke
%A Flenner, Silja
%A Will, Olga
%A Beuer, Susanne
%A Wieland, D. C Florian
%A Willumeit-Römer, Regine
%A Zeller-Plumhoff, Berit
%T Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants
%J Bioactive materials
%V 30
%@ 2097-1192
%C [Amsterdam]
%I Elsevier B.V.
%M PUBDB-2023-05209
%P 154 - 168
%D 2023
%X The utilization of biodegradable magnesium (Mg)-based implants for restoration of bone function following trauma represents a transformative approach in orthopaedic application. One such alloy, magnesium-10 weight percent gadolinium (Mg-10Gd), has been specifically developed to address the rapid degradation of Mg while enhancing its mechanical properties to promote bone healing. Previous studies have demonstrated that Mg-10Gd exhibits favorable osseointegration; however, it exhibits distinct ultrastructural adaptation in comparison to conventional implants like titanium (Ti). A crucial aspect that remains unexplored is the impact of Mg-10Gd degradation on the bone microarchitecture. To address this, we employed hierarchical three-dimensional imaging using synchrotron radiation in conjunction with image-based finite element modelling. By using the methods outlined, the vascular porosity, lacunar porosity and the lacunar-canaliculi network (LCN) morphology of bone around Mg-10Gd in comparison to Ti in a rat model from 4 weeks to 20 weeks post-implantation was investigated. Our investigation revealed that within our observation period, the degradation of Mg-10Gd implants was associated with significantly lower (p < 0.05) lacunar density in the surrounding bone, compared to Ti. Remarkably, the LCN morphology and the fluid flow analysis did not significantly differ for both implant types. In summary, a more pronounced lower lacunae distribution rather than their morphological changes was detected in the surrounding bone upon the degradation of Mg-10Gd implants. This implies potential disparities in bone remodelling rates when compared to Ti implants. Our findings shed light on the intricate relationship between Mg-10Gd degradation and bone microarchitecture, contributing to a deeper understanding of the implications for successful osseointegration. 
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 37575877
%U <Go to ISI:>//WOS:001053239200001
%R 10.1016/j.bioactmat.2023.07.017
%U https://bib-pubdb1.desy.de/record/589466