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000589466 1001_ $$0P:(DE-H253)PIP1093130$$aSefa, Sandra$$b0$$eCorresponding author
000589466 245__ $$aMultiscale morphological analysis of bone microarchitecture around Mg-10Gd implants
000589466 260__ $$a[Amsterdam]$$bElsevier B.V.$$c2023
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000589466 520__ $$aThe utilization of biodegradable magnesium (Mg)-based implants for restoration of bone function following trauma represents a transformative approach in orthopaedic application. One such alloy, magnesium-10 weight percent gadolinium (Mg-10Gd), has been specifically developed to address the rapid degradation of Mg while enhancing its mechanical properties to promote bone healing. Previous studies have demonstrated that Mg-10Gd exhibits favorable osseointegration; however, it exhibits distinct ultrastructural adaptation in comparison to conventional implants like titanium (Ti). A crucial aspect that remains unexplored is the impact of Mg-10Gd degradation on the bone microarchitecture. To address this, we employed hierarchical three-dimensional imaging using synchrotron radiation in conjunction with image-based finite element modelling. By using the methods outlined, the vascular porosity, lacunar porosity and the lacunar-canaliculi network (LCN) morphology of bone around Mg-10Gd in comparison to Ti in a rat model from 4 weeks to 20 weeks post-implantation was investigated. Our investigation revealed that within our observation period, the degradation of Mg-10Gd implants was associated with significantly lower (p < 0.05) lacunar density in the surrounding bone, compared to Ti. Remarkably, the LCN morphology and the fluid flow analysis did not significantly differ for both implant types. In summary, a more pronounced lower lacunae distribution rather than their morphological changes was detected in the surrounding bone upon the degradation of Mg-10Gd implants. This implies potential disparities in bone remodelling rates when compared to Ti implants. Our findings shed light on the intricate relationship between Mg-10Gd degradation and bone microarchitecture, contributing to a deeper understanding of the implications for successful osseointegration. 
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000589466 7001_ $$aEspiritu, Jonathan$$b1
000589466 7001_ $$0P:(DE-H253)PIP1088402$$aĆwieka, Hanna$$b2
000589466 7001_ $$0P:(DE-H253)PIP1009579$$aGreving, Imke$$b3
000589466 7001_ $$0P:(DE-H253)PIP1030015$$aFlenner, Silja$$b4
000589466 7001_ $$aWill, Olga$$b5
000589466 7001_ $$aBeuer, Susanne$$b6
000589466 7001_ $$00000-0002-8594-8292$$aWieland, D. C Florian$$b7
000589466 7001_ $$aWillumeit-Römer, Regine$$b8
000589466 7001_ $$0P:(DE-H253)PIP1031548$$aZeller-Plumhoff, Berit$$b9$$eCorresponding author
000589466 773__ $$0PERI:(DE-600)2970496-0$$a10.1016/j.bioactmat.2023.07.017$$gVol. 30, p. 154 - 168$$p154 - 168$$tBioactive materials$$v30$$x2097-1192$$y2023
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