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@ARTICLE{Sefa:589466,
      author       = {Sefa, Sandra and Espiritu, Jonathan and Ćwieka, Hanna and
                      Greving, Imke and Flenner, Silja and Will, Olga and Beuer,
                      Susanne and Wieland, D. C Florian and Willumeit-Römer,
                      Regine and Zeller-Plumhoff, Berit},
      title        = {{M}ultiscale morphological analysis of bone
                      microarchitecture around {M}g-10{G}d implants},
      journal      = {Bioactive materials},
      volume       = {30},
      issn         = {2097-1192},
      address      = {[Amsterdam]},
      publisher    = {Elsevier B.V.},
      reportid     = {PUBDB-2023-05209},
      pages        = {154 - 168},
      year         = {2023},
      abstract     = {The utilization of biodegradable magnesium (Mg)-based
                      implants for restoration of bone function following trauma
                      represents a transformative approach in orthopaedic
                      application. One such alloy, magnesium-10 weight percent
                      gadolinium (Mg-10Gd), has been specifically developed to
                      address the rapid degradation of Mg while enhancing its
                      mechanical properties to promote bone healing. Previous
                      studies have demonstrated that Mg-10Gd exhibits favorable
                      osseointegration; however, it exhibits distinct
                      ultrastructural adaptation in comparison to conventional
                      implants like titanium (Ti). A crucial aspect that remains
                      unexplored is the impact of Mg-10Gd degradation on the bone
                      microarchitecture. To address this, we employed hierarchical
                      three-dimensional imaging using synchrotron radiation in
                      conjunction with image-based finite element modelling. By
                      using the methods outlined, the vascular porosity, lacunar
                      porosity and the lacunar-canaliculi network (LCN) morphology
                      of bone around Mg-10Gd in comparison to Ti in a rat model
                      from 4 weeks to 20 weeks post-implantation was investigated.
                      Our investigation revealed that within our observation
                      period, the degradation of Mg-10Gd implants was associated
                      with significantly lower (p < 0.05) lacunar density in the
                      surrounding bone, compared to Ti. Remarkably, the LCN
                      morphology and the fluid flow analysis did not significantly
                      differ for both implant types. In summary, a more pronounced
                      lower lacunae distribution rather than their morphological
                      changes was detected in the surrounding bone upon the
                      degradation of Mg-10Gd implants. This implies potential
                      disparities in bone remodelling rates when compared to Ti
                      implants. Our findings shed light on the intricate
                      relationship between Mg-10Gd degradation and bone
                      microarchitecture, contributing to a deeper understanding of
                      the implications for successful osseointegration.},
      cin          = {Hereon / DOOR ; HAS-User},
      ddc          = {630},
      cid          = {I:(DE-H253)Hereon-20210428 / I:(DE-H253)HAS-User-20120731},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P05-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37575877},
      UT           = {WOS:001053239200001},
      doi          = {10.1016/j.bioactmat.2023.07.017},
      url          = {https://bib-pubdb1.desy.de/record/589466},
}