Journal Article

PUBDB-2016-00562

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Radiation damage in a micron-sized protein crystal studied via reciprocal space mapping and Bragg coherent diffractive imaging

Coughlan, H. D. ; Darmanin, C. ; Phillips, N. W. ; Hofmann, F. ; Clark, J. (Corresponding author)CFEL*DESY* ; Harder, R. J. ; Vine, D. J. ; Abbey, B.

2015
AIP Publishing LLC Melville, NY

This record in other databases:        

Please use a persistent id in citations: doi:10.1063/1.4919641

Abstract: For laboratory and synchrotron based X-ray sources, radiation damage has posed a significant barrier to obtaining high-resolution structural data from biological macromolecules. The problem is particularly acute for micron-sized crystals where the weaker signal often necessitates the use of higher intensity beams to obtain the relevant data. Here, we employ a combination of techniques, including Bragg coherent diffractiveimaging to characterise the radiation induced damage in a micron-sized protein crystal over time. The approach we adopt here could help screen for potential protein crystal candidates for measurement at X-ray free election laser sources.

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Contributing Institute(s):

1. CFEL-Coherent X-Ray Imaging (FS-CFEL-1)

Research Program(s):

1. 6214 - Nanoscience and Materials for Information Technology (POF3-621) (POF3-621)

Experiment(s):

1. No specific instrument

Appears in the scientific report 2015

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Database coverage:
; ; SCOPUS

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