%0 Journal Article
%A Coughlan, H. D.
%A Darmanin, C.
%A Phillips, N. W.
%A Hofmann, F.
%A Clark, Jesse
%A Harder, R. J.
%A Vine, D. J.
%A Abbey, B.
%T Radiation damage in a micron-sized protein crystal studied via reciprocal space mapping and Bragg coherent diffractive imaging
%J Structural dynamics
%V 2
%N 4
%@ 2329-7778
%C Melville, NY
%I AIP Publishing LLC
%M PUBDB-2016-00562
%P 041704 -
%D 2015
%X For laboratory and synchrotron based X-ray sources, radiation damage has posed a significant barrier to obtaining high-resolution structural data from biological macromolecules. The problem is particularly acute for micron-sized crystals where the weaker signal often necessitates the use of higher intensity beams to obtain the relevant data. Here, we employ a combination of techniques, including Bragg coherent diffractiveimaging to characterise the radiation induced damage in a micron-sized protein crystal over time. The approach we adopt here could help screen for potential protein crystal candidates for measurement at X-ray free election laser sources.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000360649200006
%$ pmid:26798804
%R 10.1063/1.4919641
%U https://bib-pubdb1.desy.de/record/293473