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000293473 037__ $$aPUBDB-2016-00562
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000293473 1001_ $$aCoughlan, H. D.$$b0
000293473 245__ $$aRadiation damage in a micron-sized protein crystal studied via reciprocal space mapping and Bragg coherent diffractive imaging
000293473 260__ $$aMelville, NY$$bAIP Publishing LLC$$c2015
000293473 3367_ $$00$$2EndNote$$aJournal Article
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000293473 520__ $$aFor laboratory and synchrotron based X-ray sources, radiation damage has posed a significant barrier to obtaining high-resolution structural data from biological macromolecules. The problem is particularly acute for micron-sized crystals where the weaker signal often necessitates the use of higher intensity beams to obtain the relevant data. Here, we employ a combination of techniques, including Bragg coherent diffractiveimaging to characterise the radiation induced damage in a micron-sized protein crystal over time. The approach we adopt here could help screen for potential protein crystal candidates for measurement at X-ray free election laser sources.
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000293473 7001_ $$aDarmanin, C.$$b1
000293473 7001_ $$aPhillips, N. W.$$b2
000293473 7001_ $$aHofmann, F.$$b3
000293473 7001_ $$0P:(DE-H253)PIP1021792$$aClark, Jesse$$b4$$eCorresponding author$$udesy
000293473 7001_ $$aHarder, R. J.$$b5
000293473 7001_ $$aVine, D. J.$$b6
000293473 7001_ $$aAbbey, B.$$b7
000293473 773__ $$0PERI:(DE-600)2758684-4$$a10.1063/1.4919641$$gVol. 2, no. 4, p. 041704 -$$n4$$p041704 -$$tStructural dynamics$$v2$$x2329-7778$$y2015
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000293473 9101_ $$0I:(DE-H253)_CFEL-20120731$$6P:(DE-H253)PIP1021792$$aCentre for Free-Electron Laser Science$$b4$$kCFEL
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000293473 9141_ $$y2015
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