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| Journal Article/Contribution to a conference proceedings/Contribution to a book | PHPPUBDB-15429 |
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2009
SPIE
Bellingham, Wash.
ISBN: 9780819476357
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Please use a persistent id in citations: doi:10.1117/12.822292
Abstract: As liver fibrosis is the result of persistent necroinflammation in the liver, pro-inflammatory cytokines secreted in response to cell injury have a central role in the pathogenesis of liver fibrosis. We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B.Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B patients were determined. Severe liver fibrosis was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI 0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P = 0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no significant association with severe fibrosis. Weak linkage disequilibrium was observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627 was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production (A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI 0.39-0.99; P = 0.046).High production genotype and haplotypes of IL-10 were associated with less severe liver fibrosis in chronic hepatitis B in Chinese.
Keyword(s): Adult (MeSH) ; Female (MeSH) ; Hepatitis B, Chronic: complications (MeSH) ; Humans (MeSH) ; Interleukin 1 Receptor Antagonist Protein: genetics (MeSH) ; Interleukin-10: genetics (MeSH) ; Interleukin-1beta: genetics (MeSH) ; Liver Cirrhosis: complications (MeSH) ; Liver Cirrhosis: genetics (MeSH) ; Male (MeSH) ; Polymorphism, Genetic (MeSH) ; Tumor Necrosis Factor-alpha: genetics (MeSH) ; IL1RN protein, human ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1beta ; Tumor Necrosis Factor-alpha ; Interleukin-10
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