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000089789 1001_ $$aVielhauer, S.
000089789 1112_ $$aSPIE Europe Optics and Optoelectronics$$cPrague$$d2009-04-20 - 2009-04-23$$wCzech Republic
000089789 1101_ $$aDESY$$bExperiments with synchrotron radiation
000089789 245__ $$aPhosphor materials under high-density XUV FEL excitation: mechanisms of luminescence quenching
000089789 260__ $$aBellingham, Wash.$$bSPIE$$c2009
000089789 29510 $$aDamage to VUV, EUV, and X-Ray Optics II (Proceedings Volume )
000089789 300__ $$a73610R-1 - 73610R-9
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000089789 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$mcontb
000089789 440_0 $$aSPIE Proceedings$$v7361
000089789 500__ $$3Converted on 2013-05-30 13:46
000089789 500__ $$3Converted on 2013-06-21 19:20
000089789 520__ $$aAs liver fibrosis is the result of persistent necroinflammation in the liver, pro-inflammatory cytokines secreted in response to cell injury have a central role in the pathogenesis of liver fibrosis. We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B.Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B patients were determined. Severe liver fibrosis was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI 0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P = 0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no significant association with severe fibrosis. Weak linkage disequilibrium was observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627 was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production (A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI 0.39-0.99; P = 0.046).High production genotype and haplotypes of IL-10 were associated with less severe liver fibrosis in chronic hepatitis B in Chinese.
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000089789 650_7 $$00$$2NLM Chemicals$$aIL1RN protein, human
000089789 650_7 $$00$$2NLM Chemicals$$aInterleukin 1 Receptor Antagonist Protein
000089789 650_7 $$00$$2NLM Chemicals$$aInterleukin-1beta
000089789 650_7 $$00$$2NLM Chemicals$$aTumor Necrosis Factor-alpha
000089789 650_7 $$0130068-27-8$$2NLM Chemicals$$aInterleukin-10
000089789 650_2 $$2MeSH$$aAdult
000089789 650_2 $$2MeSH$$aFemale
000089789 650_2 $$2MeSH$$aHepatitis B, Chronic: complications
000089789 650_2 $$2MeSH$$aHumans
000089789 650_2 $$2MeSH$$aInterleukin 1 Receptor Antagonist Protein: genetics
000089789 650_2 $$2MeSH$$aInterleukin-10: genetics
000089789 650_2 $$2MeSH$$aInterleukin-1beta: genetics
000089789 650_2 $$2MeSH$$aLiver Cirrhosis: complications
000089789 650_2 $$2MeSH$$aLiver Cirrhosis: genetics
000089789 650_2 $$2MeSH$$aMale
000089789 650_2 $$2MeSH$$aPolymorphism, Genetic
000089789 650_2 $$2MeSH$$aTumor Necrosis Factor-alpha: genetics
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000089789 7001_ $$aBabin, V.
000089789 7001_ $$ade Grazia, M.
000089789 7001_ $$aFeldbach, E.
000089789 7001_ $$aKirm, M.
000089789 7001_ $$aNagirnyi, V.
000089789 7001_ $$aVasilev, A.
000089789 7001_ $$aJuha, L.
000089789 7001_ $$aBajt, S.
000089789 7001_ $$aSobierajski, R.
000089789 773__ $$0PERI:(DE-600)2398361-9$$a10.1117/12.822292$$gVol. 7361, p. 73610R-1 - 73610R-9$$p73610R-1 - 73610R-9$$q7361<73610R-1 - 73610R-9$$tProceedings of SPIE$$v7361$$x1996-756X$$y2009
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