Journal Article

PHPPUBDB-8264

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

Laib, S. ; Fellah, B. H. ; Fatimi, A. ; Quillard, S. ; Vinatier, C. ; Gauthier, O. ; Janvier, P. ; Petit, M. ; Bujoli, B. ; Bohic, S. ; Weiss, P. ; DESY

2009
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.biomaterials.2008.11.031

Abstract: In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.

Keyword(s): Absorbable Implants (MeSH) ; Animals (MeSH) ; Biocompatible Materials: metabolism (MeSH) ; Bone and Bones: drug effects (MeSH) ; Bone and Bones: metabolism (MeSH) ; Calcium Phosphates: metabolism (MeSH) ; Cell Line (MeSH) ; Cell Survival: drug effects (MeSH) ; Cells, Cultured (MeSH) ; Ceramics: metabolism (MeSH) ; Chondrocytes: cytology (MeSH) ; Chondrocytes: drug effects (MeSH) ; Cross-Linking Reagents: pharmacology (MeSH) ; Femur: pathology (MeSH) ; Femur: ultrastructure (MeSH) ; Humans (MeSH) ; Hydrogel: metabolism (MeSH) ; Methylcellulose: analogs & derivatives (MeSH) ; Methylcellulose: chemistry (MeSH) ; Methylcellulose: metabolism (MeSH) ; N-Acetylneuraminic Acid: chemistry (MeSH) ; N-Acetylneuraminic Acid: metabolism (MeSH) ; Osteogenesis: drug effects (MeSH) ; Prosthesis Implantation (MeSH) ; Rabbits (MeSH) ; Ruthenium: metabolism (MeSH) ; Time Factors (MeSH) ; Tissue Engineering (MeSH) ; Biocompatible Materials ; Calcium Phosphates ; Ceramics ; Cross-Linking Reagents ; N-Acetylneuraminic Acid ; Hydrogel ; Ruthenium ; hypromellose ; Methylcellulose ; calcium phosphate

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Contributing Institute(s):

1. Experiments with synchrotron radiation (HASYLAB)

Research Program(s):

1. DORIS Beamline L (POF1-550) (POF1-550)
2. FS-Proposal: I-20070089 EC (I-20070089-EC) (I-20070089-EC)

Experiment(s):

1. DORIS Beamline L (DORIS III)

Appears in the scientific report 2009

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Database coverage:
; ; JCR ; No Author Disambiguation ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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