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@ARTICLE{Laib:87279,
      author       = {Laib, S. and Fellah, B. H. and Fatimi, A. and Quillard, S.
                      and Vinatier, C. and Gauthier, O. and Janvier, P. and Petit,
                      M. and Bujoli, B. and Bohic, S. and Weiss, P. and DESY},
      title        = {{T}he in vivo degradation of a ruthenium labelled
                      polysaccharide-based hydrogel for bone tissue engineering},
      journal      = {Biomaterials},
      volume       = {30},
      issn         = {0142-9612},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PHPPUBDB-8264},
      pages        = {1568-1577},
      year         = {2009},
      abstract     = {In this paper we report a new method that permitted for the
                      first time to selectively track a polysaccharide-based
                      hydrogel on bone tissue explants, several weeks after its
                      implantation. The hydrogel, which was developed for bone
                      healing and tissue engineering, was labelled with a
                      ruthenium complex and implanted into rabbit bone defects in
                      order to investigate its in vivo degradation. 1, 2, 3 and 8
                      weeks after surgery, the bone explants were analyzed by
                      synchrotron X-ray microfluorescence, infrared mapping
                      spectroscopy, scanning electron microscopy, and optical
                      microscopy after histological coloration. The results showed
                      that the labelled polysaccharide-based hydrogel was likely
                      to undergo phagocytosis that seemed to occur from the edge
                      to the center of the implantation site up to at least the
                      8th week.},
      keywords     = {Absorbable Implants / Animals / Biocompatible Materials:
                      metabolism / Bone and Bones: drug effects / Bone and Bones:
                      metabolism / Calcium Phosphates: metabolism / Cell Line /
                      Cell Survival: drug effects / Cells, Cultured / Ceramics:
                      metabolism / Chondrocytes: cytology / Chondrocytes: drug
                      effects / Cross-Linking Reagents: pharmacology / Femur:
                      pathology / Femur: ultrastructure / Humans / Hydrogel:
                      metabolism / Methylcellulose: analogs $\&$ derivatives /
                      Methylcellulose: chemistry / Methylcellulose: metabolism /
                      N-Acetylneuraminic Acid: chemistry / N-Acetylneuraminic
                      Acid: metabolism / Osteogenesis: drug effects / Prosthesis
                      Implantation / Rabbits / Ruthenium: metabolism / Time
                      Factors / Tissue Engineering / Biocompatible Materials (NLM
                      Chemicals) / Calcium Phosphates (NLM Chemicals) / Ceramics
                      (NLM Chemicals) / Cross-Linking Reagents (NLM Chemicals) /
                      N-Acetylneuraminic Acid (NLM Chemicals) / Hydrogel (NLM
                      Chemicals) / Ruthenium (NLM Chemicals) / hypromellose (NLM
                      Chemicals) / Methylcellulose (NLM Chemicals) / calcium
                      phosphate (NLM Chemicals)},
      cin          = {HASYLAB},
      ddc          = {570},
      cid          = {$I:(DE-H253)HASYLAB_-2012_-20130307$},
      pnm          = {DORIS Beamline L (POF1-550) / FS-Proposal: I-20070089 EC
                      (I-20070089-EC)},
      pid          = {G:(DE-H253)POF1-L-20130405 / G:(DE-H253)I-20070089-EC},
      experiment   = {EXP:(DE-H253)D-L-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19101030},
      UT           = {WOS:000263402500013},
      doi          = {10.1016/j.biomaterials.2008.11.031},
      url          = {https://bib-pubdb1.desy.de/record/87279},
}