%0 Journal Article
%A Laib, S.
%A Fellah, B. H.
%A Fatimi, A.
%A Quillard, S.
%A Vinatier, C.
%A Gauthier, O.
%A Janvier, P.
%A Petit, M.
%A Bujoli, B.
%A Bohic, S.
%A Weiss, P.
%A DESY
%T The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering
%J Biomaterials
%V 30
%@ 0142-9612
%C Amsterdam [u.a.]
%I Elsevier Science
%M PHPPUBDB-8264
%P 1568-1577
%D 2009
%X In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.
%K Absorbable Implants
%K Animals
%K Biocompatible Materials: metabolism
%K Bone and Bones: drug effects
%K Bone and Bones: metabolism
%K Calcium Phosphates: metabolism
%K Cell Line
%K Cell Survival: drug effects
%K Cells, Cultured
%K Ceramics: metabolism
%K Chondrocytes: cytology
%K Chondrocytes: drug effects
%K Cross-Linking Reagents: pharmacology
%K Femur: pathology
%K Femur: ultrastructure
%K Humans
%K Hydrogel: metabolism
%K Methylcellulose: analogs & derivatives
%K Methylcellulose: chemistry
%K Methylcellulose: metabolism
%K N-Acetylneuraminic Acid: chemistry
%K N-Acetylneuraminic Acid: metabolism
%K Osteogenesis: drug effects
%K Prosthesis Implantation
%K Rabbits
%K Ruthenium: metabolism
%K Time Factors
%K Tissue Engineering
%K Biocompatible Materials (NLM Chemicals)
%K Calcium Phosphates (NLM Chemicals)
%K Ceramics (NLM Chemicals)
%K Cross-Linking Reagents (NLM Chemicals)
%K N-Acetylneuraminic Acid (NLM Chemicals)
%K Hydrogel (NLM Chemicals)
%K Ruthenium (NLM Chemicals)
%K hypromellose (NLM Chemicals)
%K Methylcellulose (NLM Chemicals)
%K calcium phosphate (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:19101030
%U <Go to ISI:>//WOS:000263402500013
%R 10.1016/j.biomaterials.2008.11.031
%U https://bib-pubdb1.desy.de/record/87279