Poster

PUBDB-2026-00240

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png NORMAL TISSUE SPARING WITH ELECTRON BEAMS AT PITZ: FIRST IRRADIATION STUDY IN ZEBRAFISH EMBRYOS

Tarakci, E. (Corresponding author)DESY*

2025

Abstract: FLASH irradiation has emerged as a promising approach to reduce normal tissue toxicity while preserving tumor control, creating a need for sensitive models to study its biological effects. Zebrafish (Danio rerio) embryos provide such a model, offering a vertebrate system with high developmental sensitivity, genetic similarity to humans, and suitability for preclinical radiation biology research. Within the R&D platform FLASHlab@PITZ, a collaboration between the Photo Injector Test Facility at DESY in Zeuthen (PITZ), the Technical University of Applied Sciences Wildau, Charité – Universitätsmedizin Berlin, and the Max-Delbrück Center (MDC), we aim to establish zebrafish as a robust in vivo system to characterize radiation-induced toxicities. In this study, we evaluated the effects of conventional X-rays, electron low dose rate (LDR), and electron high dose rate (HDR, FLASH-like) irradiation on wild-type AB zebrafish embryos at 24 hours post-fertilization (hpf).

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Contributing Institute(s):

1. Technologie (Z_PITZ)

Research Program(s):

1. 621 - Accelerator Research and Development (POF4-621) (POF4-621)

Experiment(s):

1. Photo Injector Test Facility

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