Documents in process

Control of posttranscriptional mRNA decay is a crucial determinant of cell homeostasis and differentiation. mRNA lifetime is governed by cis-regulatory elements in their 3′ untranslated regions (UTR). [...]

The Kaposi’s sarcoma associated herpesvirus protein ORF45 binds the extracellular signal-regulated kinase (ERK) and the p90 Ribosomal S6 kinase (RSK). ORF45 was shown to be a kinase activator in cells but a kinase inhibitor in vitro, and its effects on the ERK-RSK complex are unknown. [...]

Astrophysical neutrinos are excellent probes of astroparticle physics and high-energy physics. With energies far beyond solar, supernovae, atmospheric, and accelerator neutrinos, high-energy and ultra-high-energy neutrinos probe fundamental physics from the TeV scale to the EeV scale and beyond. [...]

Aims: This study aimed to investigate gadolinium (Gd) and bio-metals in a renal allograft of a patient who was shortly after transplantation repeatedly exposed to a Gd-based contrast agent (GBCA), with the purpose of determining whether Gd can be proven and spatially and quantitatively imaged. Further elemental associations between Gd and bio-metals were also investigated. [...]

The recently discovered lytic polysaccharide monooxygenases (LPMOs) are Cu-containing enzymes capable of degrading polysaccharide substrates oxidatively. The generally accepted first step in the LPMO reaction is the reduction of the active-site metal ion from Cu2+ to Cu+. [...]

In this work, a 316L stainless steel to Inconel 625 functionally graded material (FGM) wasbuilt using different deposition strategies (named as direct and smooth-type interfaces) byTwin-Wire and Arc Additive Manufacturing (T-WAAM). This combination of materials is ofinterest in chemical plants, oil & gas, and nuclear applications, where high corrosion andwear resistance are essential requirements. [...]

The central region of the Milky Way is one of the foremost locations to look for dark matter (DM) signatures. We report the first results on a search for DM particle annihilation signals using new observations from an unprecedented γ-ray survey of the Galactic Center (GC) region, i.e., the Inner Galaxy Survey, at very high energies (≳100 GeV) performed with the H.E.S.S. [...]

Within an effective field theory method to general relativity, we calculate the fifth-order post–Newtonian (5PN) Hamiltonian dynamics also for the tail terms, extending earlier work on the potential contributions, working in harmonic coordinates. Here we calculate independently all (local) 5PN far-zone contributions using the in–in formalism, on which we give a detailed account. [...]