Journal Article

PUBDB-2025-02329

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Interfacing B‐DNA and DNA Mimic Foldamers

Loos, M. ; Xu, F. ; Mandal, P. K. ; Chakrabortty, T. ; Douat, C. ; Konrad, D. B. ; Cabbar, M. ; Singer, J. ; Corvaglia, V. ; Carell, T. ; Huc, I. (Corresponding author)

2025
Wiley-VCH Weinheim

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Please use a persistent id in citations: doi:10.1002/anie.202505273  doi:10.3204/PUBDB-2025-02329

Abstract: A linker unit was designed and synthesized that can serve both as a hairpin turn in a DNA duplex and anchor point for an aromatic helical foldamer mimicking the shape and surface properties of B-DNA. Methods were developed to synthesize natural/non-natural chimeric molecules combining foldamer and DNA segments. The ability of the linker to position the foldamer helix and the duplex DNA so that their rims and grooves are in register, despite their completely different chemical nature, was demonstrated using single crystal X-ray diffraction, circular dichroism and molecular models. Bio-layer interferometry confirmed that artificial hairpin DNA duplexes keep their ability to bind to DNA binding proteins. The chimeric molecules may pave the way to competitive inhibitors of protein-DNA interactions involving sequence-selective DNA-binding proteins.

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Contributing Institute(s):

1. EMBL-User (EMBL-User)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
2. SFB 1309 A03 - Effekte von DNA-Modifikationen auf Stabilität und Mobilität von Histonproteinen (A03) (401882400) (401882400)
3. SFB 1309 C07 - Molekulare Werkzeuge auf der Basis aromatischer Foldamere zur Interferenz mit und Investigation von epigenetischen Proteinen (C07*) (504753833) (504753833)
4. SFB 1361 02 - Bildung und Analyse von DNA-Protein-Querverbindungen (02) (418751154) (418751154)
5. DFG project 518800810 - Chemische Biologie der intrazellulären Nukleinsäureerkennung (A27*) (518800810) (518800810)
6. A2F2 - Beyond Biopolymers: Protein-Sized Aromatic Amide Functional Foldamers (320892) (320892)
7. NATURE-ETN - Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification (861381) (861381)

Experiment(s):

1. PETRA Beamline P13 (PETRA III)
2. PETRA Beamline P14 (PETRA III)

Appears in the scientific report 2025

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Database coverage:
; ; ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; Index Chemicus ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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