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@ARTICLE{Loos:633003,
      author       = {Loos, Manuel and Xu, Felix and Mandal, Pradeep K. and
                      Chakrabortty, Tulika and Douat, Céline and Konrad, David B.
                      and Cabbar, Melis and Singer, Johannes and Corvaglia,
                      Valentina and Carell, Thomas and Huc, Ivan},
      title        = {{I}nterfacing {B}‐{DNA} and {DNA} {M}imic {F}oldamers},
      journal      = {Angewandte Chemie / International edition},
      volume       = {64},
      number       = {31},
      issn         = {1433-7851},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PUBDB-2025-02329},
      pages        = {e202505273},
      year         = {2025},
      abstract     = {A linker unit was designed and synthesized that can serve
                      both as a hairpin turn in a DNA duplex and anchor point for
                      an aromatic helical foldamer mimicking the shape and surface
                      properties of B-DNA. Methods were developed to synthesize
                      natural/non-natural chimeric molecules combining foldamer
                      and DNA segments. The ability of the linker to position the
                      foldamer helix and the duplex DNA so that their rims and
                      grooves are in register, despite their completely different
                      chemical nature, was demonstrated using single crystal X-ray
                      diffraction, circular dichroism and molecular models.
                      Bio-layer interferometry confirmed that artificial hairpin
                      DNA duplexes keep their ability to bind to DNA binding
                      proteins. The chimeric molecules may pave the way to
                      competitive inhibitors of protein-DNA interactions involving
                      sequence-selective DNA-binding proteins.},
      cin          = {EMBL-User},
      ddc          = {540},
      cid          = {I:(DE-H253)EMBL-User-20120814},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3) / SFB 1309 A03 - Effekte
                      von DNA-Modifikationen auf Stabilität und Mobilität von
                      Histonproteinen (A03) (401882400) / SFB 1309 C07 -
                      Molekulare Werkzeuge auf der Basis aromatischer Foldamere
                      zur Interferenz mit und Investigation von epigenetischen
                      Proteinen (C07*) (504753833) / SFB 1361 02 - Bildung und
                      Analyse von DNA-Protein-Querverbindungen (02) (418751154) /
                      DFG project 518800810 - Chemische Biologie der
                      intrazellulären Nukleinsäureerkennung (A27*) (518800810) /
                      A2F2 - Beyond Biopolymers: Protein-Sized Aromatic Amide
                      Functional Foldamers (320892) / NATURE-ETN - Nucleic Acids
                      for Future Gene Editing, Immunotherapy and Epigenetic
                      Sequence Modification (861381)},
      pid          = {G:(DE-HGF)POF4-6G3 / G:(GEPRIS)401882400 /
                      G:(GEPRIS)504753833 / G:(GEPRIS)418751154 /
                      G:(GEPRIS)518800810 / G:(EU-Grant)320892 /
                      G:(EU-Grant)861381},
      experiment   = {EXP:(DE-H253)P-P13-20150101 / EXP:(DE-H253)P-P14-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40346004},
      doi          = {10.1002/anie.202505273},
      url          = {https://bib-pubdb1.desy.de/record/633003},
}