TY  - JOUR
AU  - Loos, Manuel
AU  - Xu, Felix
AU  - Mandal, Pradeep K.
AU  - Chakrabortty, Tulika
AU  - Douat, Céline
AU  - Konrad, David B.
AU  - Cabbar, Melis
AU  - Singer, Johannes
AU  - Corvaglia, Valentina
AU  - Carell, Thomas
AU  - Huc, Ivan
TI  - Interfacing B‐DNA and DNA Mimic Foldamers
JO  - Angewandte Chemie / International edition
VL  - 64
IS  - 31
SN  - 1433-7851
CY  - Weinheim
PB  - Wiley-VCH
M1  - PUBDB-2025-02329
SP  - e202505273
PY  - 2025
AB  - A linker unit was designed and synthesized that can serve both as a hairpin turn in a DNA duplex and anchor point for an aromatic helical foldamer mimicking the shape and surface properties of B-DNA. Methods were developed to synthesize natural/non-natural chimeric molecules combining foldamer and DNA segments. The ability of the linker to position the foldamer helix and the duplex DNA so that their rims and grooves are in register, despite their completely different chemical nature, was demonstrated using single crystal X-ray diffraction, circular dichroism and molecular models. Bio-layer interferometry confirmed that artificial hairpin DNA duplexes keep their ability to bind to DNA binding proteins. The chimeric molecules may pave the way to competitive inhibitors of protein-DNA interactions involving sequence-selective DNA-binding proteins.
LB  - PUB:(DE-HGF)16
C6  - pmid:40346004
DO  - DOI:10.1002/anie.202505273
UR  - https://bib-pubdb1.desy.de/record/633003
ER  -