Journal Article

PUBDB-2025-04338

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Protein Target Highlights in CASP16 : Insights From the Structure Providers

Alexander, L. T. (Corresponding author) ; Follonier, O. M. ; Kryshtafovych, A. ; Abesamis, K. ; Bibi-Triki, S. ; Box, H. G. ; Breyton, C. ; Bringel, F. ; Carrique, L. ; d'Acapito, A. ; Dong, G. ; DuBois, R. ; Fass, D. ; Fiesco, J. M. ; Fox, D. R. ; Grimes, J. M. ; Grinter, R. ; Jenkins, M. ; Kamyshinsky, R. ; Keown, J. R. ; Lackner, G. ; Lammers, M. ; Liu, S. ; Lovering, A. L. ; Malinauskas, T. ; Masquida, B. ; Palm, G. J. ; Siebold, C. ; Su, T. ; Zhang, P. ; Zhou, Z. H. ; Fidelis, K. ; Topf, M.Extern*CSSB* ; Moult, J. ; Schwede, T.

2025
Wiley-Liss New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/prot.70025  doi:10.3204/PUBDB-2025-04338

Abstract: This article presents an in-depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions. While the overall performance of structure prediction methods remains impressive, challenges persist, particularly in modeling rare structural motifs, flexible regions, small molecule interactions, posttranslational modifications, and biologically important interfaces. Addressing these limitations can strengthen the role of structure prediction in complementing experimental efforts and advancing both basic research and biomedical applications.

Note: Please delete CSSB-LIV/DESY-CU and add CSSB-LIV/UKE-MT. I entered it incorrectly.

---

Contributing Institute(s):

1. CSSB - Leibniz-Institut für Experimentelle Virologie (LIV) / UKE - Maya Topf (CSSB-LIV/UKE-MT)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Experiment(s):

1. No specific instrument

Appears in the scientific report 2025

---

Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---