Journal Article

PUBDB-2025-02347

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cholesterol modulated assembly of graphene oxide nano-flakes at a phospholipid interface

Seth, A.Extern* ; Giri, R. P.Extern* ; Hayen, N. ; hitaishi, p.Extern* ; Murphy, B. M.Extern*XFEL.EU*DESY* ; Ghosh, S. K. (Corresponding author)Extern*

2025
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.colsurfb.2025.114934  doi:10.3204/PUBDB-2025-02347

Abstract: Cholesterol, a key structural component of mammalian cell membranes, is crucial in stabilizing the membraneand regulating its biophysical properties. Herein, the self-assembly of graphene oxide (GO) around differentlycharged lipid monolayers modulated by cholesterol has been investigated using surface pressure-area isothermsand synchrotron-based X-ray reflectivity. In pristine lipid monolayers, electrostatic interactions control the selfassemblyof GO nano-flakes around the lipid molecules. However, upon the addition of cholesterol, theadsorption and penetration kinetics of GO nano-flakes into the lipid monolayers are drastically amplified, irrespectiveof the ionic nature of lipids. The experimental observations are discussed in terms of interactionsoccurring among GO nano-flakes, phospholipids, and cholesterol molecules.

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Contributing Institute(s):

1. FS DOOR-User (FS DOOR-User)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
2. FS-Proposal: I-20211086 (I-20211086) (I-20211086)
3. INDIA-DESY - INDIA-DESY Collaboration (2020_Join2-INDIA-DESY) (2020_Join2-INDIA-DESY)

Experiment(s):

1. PETRA Beamline P08 (PETRA III)

Appears in the scientific report 2025

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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