Journal Article

PUBDB-2023-06447

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Supramolecular intermediates in thermo-mechanochemical direct amidations

Stolar, T. (Corresponding author)Extern* ; Alic, J.Extern* ; Talajić, G. ; Cindro, N. ; Rubčić, M. ; Molčanov, K. ; Uzarevic, K. (Corresponding author)Extern* ; Hernandez, J. (Corresponding author)Extern*

2023
Soc. Cambridge

This record in other databases:        

Please use a persistent id in citations: doi:10.1039/D3CC04448C

Abstract: We present a solvent-free thermo-mechanochemical approach for the direct coupling of carboxylic acids and amines, which avoids activators and additives. Detailed analysis of the reactions by ex situ and in situ monitoring methods led to the observation, isolation, and characterisation of multicomponent crystalline intermediates that precede the formation of amides. We applied our methodology for the quantitative synthesis of the active pharmaceutical ingredient moclobemide.

Note: Waiting for fulltext

---

Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)

Research Program(s):

1. 6G3 - PETRA III (DESY) (POF4-6G3) (POF4-6G3)
2. FS-Proposal: I-20220019 EC (I-20220019-EC) (I-20220019-EC)

Experiment(s):

1. PETRA Beamline P02.1 (PETRA III)

Appears in the scientific report 2023

---

Database coverage:
; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; Index Chemicus ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---