TY  - JOUR
AU  - Stolar, Tomislav
AU  - Alic, Jasna
AU  - Talajić, Gregor
AU  - Cindro, Nikola
AU  - Rubčić, Mirta
AU  - Molčanov, Krešimir
AU  - Uzarevic, Krunoslav
AU  - Hernandez, Jose
TI  - Supramolecular intermediates in thermo-mechanochemical direct amidations
JO  - Chemical communications
VL  - 59
IS  - 90
SN  - 0022-4936
CY  - Cambridge
PB  - Soc.
M1  - PUBDB-2023-06447
SP  - 13490 - 13493
PY  - 2023
N1  - Waiting for fulltext 
AB  - We present a solvent-free thermo-mechanochemical approach for the direct coupling of carboxylic acids and amines, which avoids activators and additives. Detailed analysis of the reactions by ex situ and in situ monitoring methods led to the observation, isolation, and characterisation of multicomponent crystalline intermediates that precede the formation of amides. We applied our methodology for the quantitative synthesis of the active pharmaceutical ingredient moclobemide.
LB  - PUB:(DE-HGF)16
C6  - 37882212
UR  - <Go to ISI:>//WOS:001087332000001
DO  - DOI:10.1039/D3CC04448C
UR  - https://bib-pubdb1.desy.de/record/597157
ER  -