%0 Journal Article
%A Stolar, Tomislav
%A Alic, Jasna
%A Talajić, Gregor
%A Cindro, Nikola
%A Rubčić, Mirta
%A Molčanov, Krešimir
%A Uzarevic, Krunoslav
%A Hernandez, Jose
%T Supramolecular intermediates in thermo-mechanochemical direct amidations
%J Chemical communications
%V 59
%N 90
%@ 0022-4936
%C Cambridge
%I Soc.
%M PUBDB-2023-06447
%P 13490 - 13493
%D 2023
%Z Waiting for fulltext 
%X We present a solvent-free thermo-mechanochemical approach for the direct coupling of carboxylic acids and amines, which avoids activators and additives. Detailed analysis of the reactions by ex situ and in situ monitoring methods led to the observation, isolation, and characterisation of multicomponent crystalline intermediates that precede the formation of amides. We applied our methodology for the quantitative synthesis of the active pharmaceutical ingredient moclobemide.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 37882212
%U <Go to ISI:>//WOS:001087332000001
%R 10.1039/D3CC04448C
%U https://bib-pubdb1.desy.de/record/597157