Journal Article

PUBDB-2022-00576

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Thermodynamic and structural study of DMPC–alkanol systems

Klacsová, M. (Corresponding author) ; Bóta, A.Extern* ; Westh, P. ; Funari, S. d. S.DESY* ; Uhríková, D.Extern* ; Balgavý, P.Extern*

2021
RSC Publ. Cambridge

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Please use a persistent id in citations: doi:10.1039/D0CP04991C

Abstract: The thermodynamic and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC–CnOH, n = 8–18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0–0.8 CnOH : DMPC molar ratio range. Up to n ≤ 10 a significant biphasic effect depending on the main transition temperature t$_m$ on the CnOH concentration was observed. Two breakpoints were revealed: turning point (TP), corresponding to the minimum, and threshold concentration (c$_T$), corresponding to the end of the biphasic tendency. These breakpoints were also observed in the alkanol concentration dependent change in the enthalpy of the main transition ΔH$_m$. In the case of CnOHs with n > 10 we propose a marked shift of TP and c$_T$ to very low concentrations; consequently, only increase of tm is observed. A partial phase diagram was constructed for a pseudo-binary DMPC–C12OH system. We suggest a fluid–fluid immiscibility of the DMPC–C12OH system above c$_T$ with a consequent formation of domains with different C12OH contents. At a constant CnOH concentration, the effects of CnOHs on ΔH$_m$ and bilayer repeat distance were found to depend predominantly on the mismatch between CnOH and lipid chain lengths. Observed effects are suggested to be underlined by a counterbalancing effect of interchain van der Waals interactions and headgroup repulsion.

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Contributing Institute(s):

1. DOOR-User (DOOR ; HAS-User)
2. PETRA-D (FS-PETRA-D)

Research Program(s):

1. 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633) (POF4-633)

Experiment(s):

1. DORIS Beamline A2 (DORIS III)

Appears in the scientific report 2021

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Database coverage:
; Allianz-Lizenz / DFG ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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