%0 Journal Article
%A Klacsová, Mária
%A Bóta, Attila
%A Westh, Peter
%A Funari, Sergio de Souza
%A Uhríková, Daniela
%A Balgavý, Pavol
%T Thermodynamic and structural study of DMPC–alkanol systems
%J Physical chemistry, chemical physics
%V 23
%N 14
%@ 1463-9076
%C Cambridge
%I RSC Publ.
%M PUBDB-2022-00576
%P 8598 - 8606
%D 2021
%Z Waiting for fulltext
%X The thermodynamic and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC–CnOH, n = 8–18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0–0.8 CnOH : DMPC molar ratio range. Up to n ≤ 10 a significant biphasic effect depending on the main transition temperature t<sub>m</sub> on the CnOH concentration was observed. Two breakpoints were revealed: turning point (TP), corresponding to the minimum, and threshold concentration (c<sub>T</sub>), corresponding to the end of the biphasic tendency. These breakpoints were also observed in the alkanol concentration dependent change in the enthalpy of the main transition ΔH<sub>m</sub>. In the case of CnOHs with n > 10 we propose a marked shift of TP and c<sub>T</sub> to very low concentrations; consequently, only increase of tm is observed. A partial phase diagram was constructed for a pseudo-binary DMPC–C12OH system. We suggest a fluid–fluid immiscibility of the DMPC–C12OH system above c<sub>T</sub> with a consequent formation of domains with different C12OH contents. At a constant CnOH concentration, the effects of CnOHs on ΔH<sub>m</sub> and bilayer repeat distance were found to depend predominantly on the mismatch between CnOH and lipid chain lengths. Observed effects are suggested to be underlined by a counterbalancing effect of interchain van der Waals interactions and headgroup repulsion.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 33876021
%U <Go to ISI:>//WOS:000633043800001
%R 10.1039/D0CP04991C
%U https://bib-pubdb1.desy.de/record/474186