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001     474186
005     20240110163855.0
024 7 _ |a 10.1039/D0CP04991C
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100 1 _ |a Klacsová, Mária
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245 _ _ |a Thermodynamic and structural study of DMPC–alkanol systems
260 _ _ |a Cambridge
|c 2021
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520 _ _ |a The thermodynamic and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC–CnOH, n = 8–18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0–0.8 CnOH : DMPC molar ratio range. Up to n ≤ 10 a significant biphasic effect depending on the main transition temperature t$_m$ on the CnOH concentration was observed. Two breakpoints were revealed: turning point (TP), corresponding to the minimum, and threshold concentration (c$_T$), corresponding to the end of the biphasic tendency. These breakpoints were also observed in the alkanol concentration dependent change in the enthalpy of the main transition ΔH$_m$. In the case of CnOHs with n > 10 we propose a marked shift of TP and c$_T$ to very low concentrations; consequently, only increase of tm is observed. A partial phase diagram was constructed for a pseudo-binary DMPC–C12OH system. We suggest a fluid–fluid immiscibility of the DMPC–C12OH system above c$_T$ with a consequent formation of domains with different C12OH contents. At a constant CnOH concentration, the effects of CnOHs on ΔH$_m$ and bilayer repeat distance were found to depend predominantly on the mismatch between CnOH and lipid chain lengths. Observed effects are suggested to be underlined by a counterbalancing effect of interchain van der Waals interactions and headgroup repulsion.
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700 1 _ |a Bóta, Attila
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700 1 _ |a Westh, Peter
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700 1 _ |a Funari, Sergio de Souza
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700 1 _ |a Uhríková, Daniela
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700 1 _ |a Balgavý, Pavol
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773 _ _ |a 10.1039/D0CP04991C
|g Vol. 23, no. 14, p. 8598 - 8606
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|t Physical chemistry, chemical physics
|v 23
|y 2021
|x 1463-9076
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